CD8

·May 14, 2020·4 min read

Local inflammatory cells are characteristic for advanced multiple sclerosis

In late-stage multiple sclerosis, inflammatory cells no longer enter the brain via the bloodstream, but instead the cells arise in memory from local memory cells inside the brain. The findings suggest during the late phases of multiple sclerosis, the disease is occurring entirely inside the brain.

This is a drawing of a brain in a castle

Brain Cancer Featured Genetics Neurology Neuroscience

·January 15, 2020·3 min read

Scientists breach brain barriers to attack tumors

Introducing VEGF-C into the cerebrospinal fluid of mouse models of glioblastoma, researchers noted increased levels of T cell response to the cancerous tumors. When combined with immune system checkpoint inhibitors, the VEGF-C treatment significantly extended the life span of the mice with glioblastoma brain cancer.

Featured Neuroscience Open Neuroscience Articles

·October 14, 2019·4 min read

Gut immunity more developed before birth than previously thought

The fetal gut has far better developed immune capabilities than previously thought. The findings could help develop new maternal vaccines and provide early insight into potential autoimmune disorders, which may occur later in life.

This diagram shows how ms affects the body

Featured Neurology Neuroscience

·May 8, 2019·4 min read

A new culprit for multiple sclerosis relapses

Injecting extracellular vesicles from healthy mice into mice that had an MS-like disease resulted in the development of a relapse-remitting disease and active CD8+ cells, similar to that seen in human patients with multiple sclerosis. Examining the EVs in mice and humans with MS, researchers identified they contained fibrinogen, a protein normally associated with blood clotting and wound healing. According to researchers, the EVs with fibrinogen appear to activate the CD8+ immune cells. The findings could help with the development of new treatments for RRMS.

Featured Neurology Neuroscience

·August 31, 2018·4 min read

When Neurons Turn Against Themselves

Researchers say in some autoimmune disorders, such as Rasmussen's encephalitis, neurons are not only the targets for immune system attacks, but may also be active protagonists.

Featured Neurology

·July 2, 2018·4 min read

CMV Virus May Boost Our Immune System

Researchers report the cytomegalovirus may actually boost, not weaken, our immune systems.

Featured Genetics Neurology

·May 15, 2018·4 min read

First Clues to the Causes of Multiple Sclerosis

Researchers report TOX, a DNA binding factor, may play a significant role in triggering multiple sclerosis. The study reports TOX promotes T cells to initiate autoimmune tissue destruction in the brain.