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CAR-t

Brain Cancer Featured Neurology Neuroscience

·July 1, 2026·11 min read

CAR-T Cell Therapy Eradicates Glioblastoma

A new study demonstrates a new CAR-T cell therapy that targets the GPNMB protein found on both glioblastoma cells and tumor-supporting macrophages.

Brain Cancer Featured Neurology Neuroscience

·May 13, 2025·7 min read

CAR-T Brain Fog Mirrors Chemo and COVID

Patients receiving CAR-T cell therapy often report brain fog, and new research shows this cognitive impairment stems from the therapy itself, not just the cancer or other treatments. A mouse study revealed that CAR-T-induced immune responses activate brain microglia, triggering inflammation that damages myelin-producing cells, reducing signal efficiency in the brain.

Brain Cancer Featured Neurology Neuroscience

·December 9, 2024·6 min read

Lab-Grown Tumor Models Mirror Glioblastoma Treatment Response

Glioblastoma organoids, lab-grown replicas of a patient’s tumor, accurately predict how the tumor responds to CAR T cell therapy. This breakthrough allows real-time testing of therapies, showing that responses in the organoid closely mirror those in the patient.

Brain Cancer Featured Neurology Neuroscience

·September 26, 2024·5 min read

Novel CAR-T Therapy Shows Promise in Targeting Glioblastoma

Researchers have developed a promising CAR-T cell therapy targeting glioblastoma, the most aggressive brain tumor. The therapy uses genetically modified T cells to target a specific marker on tumor cells, potentially overcoming the limitations of traditional treatments.

Brain Cancer Featured Genetics Neurology Neuroscience

·April 19, 2024·4 min read

CAR-T Trial Targets Glioblastoma Brain Cancer

Researchers initiated a pioneering clinical trial using an advanced form of CAR-T therapy, enhanced by synthetic notch (synNotch) technology, to treat glioblastoma. This trial represents a significant shift towards targeted, safer cancer therapies.

Brain Cancer Featured Neurology Neuroscience

·April 14, 2024·5 min read

Revolutionizing Glioblastoma Treatment

Researchers demonstrated significant initial success using CAR-T therapy for glioblastoma, a notoriously deadly brain cancer. They detailed the outcomes of the first three patients in a Phase 1 clinical trial who experienced dramatic tumor reductions shortly after treatment.

Brain Cancer Featured Neuroscience

·December 11, 2022·4 min read

CAR-T-Cell Shows Promise in Patients With Lymphoma of the Brain and Spinal Cord in Early Trial

Axicabtagene ciloleucel (axi-cel), a form of CAR-T therapy appears to be safe and has encouraging signs of efficacy in treating both lymphoma of the brain and spinal cord injury.

Featured Neurology Neuroscience

·December 6, 2022·5 min read

Immunotherapy Eliminates Disease-Causing Cells in Multiple Sclerosis-Like Disease

CAR-T, a therapy generally used in the treatment of cancer, has been shown to eliminate unhealthy cells that trigger autoimmunity in mouse models of multiple-sclerosis.

Brain Cancer Featured Neurology

·April 16, 2018·8 min read

Altered Immune Cells Clear Childhood Brain Tumor: Mouse Study

A fatal brain stem tumor was cleared by injecting it with engineered T-cells that recognized cancer and targeted it for destruction in mouse models, researchers report.