Prepronociceptin expressing neurons in the central amygdala become activated by consuming palatable foods. Reducing nociceptin making neurons in mice reduced binge eating when the animals had access to calorie-rich foods, without affecting the intake of ordinary dietary needs. The finding could help in the development of new therapies to combat obesity and binge eating.
NPGL, a recently discovered protein, influences fat storage in the human body, even when on a calorie restricted diet. Researchers believe this mechanism had evolutionary benefits and the protein could be a potential target to treat obesity.