A new study has revealed distinct features of the human hippocampus, a brain region critical for memory storage and retrieval, challenging the assumption that it functions like a scaled-up mouse brain. By analyzing living brain tissue from epilepsy patients, researchers found that human hippocampal CA3 neurons exhibit sparse yet highly reliable connections, optimizing memory storage and retrieval. Unlike rodent brains, these unique wiring patterns enable the human brain to encode associative memories with greater efficiency.