Researchers have developed a new method that uses antibody fragments encapsulated in nanomicelles which can cross the blood-brain barrier and reduce levels of amyloid-beta in the brains of mouse models of Alzheimer's disease.
In those with Alzheimer's disease, the choroid plexus becomes enlarged and has increased accumulation of abnormal inflammatory signatures.
Researchers have created a new model of the blood-brain barrier that can mimic fluid flow to and from the brain.
Insulin binding receptors are predominantly located in the microvessels within the blood-brain barrier. In patients with Alzheimer's, the abundance of these receptors is decreased. This decrease could lead to the loss of insulin response in the Alzheimer's brain.
Researchers have developed a family of adeno-associated viral vectors (AAVs) that are able to cross the blood-brain barrier to deliver gene therapies directly to the brain.
A new implantable pump system safely and effectively bypasses the blood-brain barrier to deliver chemotherapy drugs to those with glioblastoma brain cancer.
The signals that originate in the cells of the blood-brain barrier also play a direct role in controlling what happens to the neurons the barrier is protecting.
Researchers have developed drug-carrying nanoparticles that cross the blood-brain barrier, allowing for more effective delivery to the brain than conventional medications. The nanoparticles can get into tumors and kill glioblastoma brain cancer cells.
New findings reveal phagocytes do not fully mature until after birth, contradicting previous assumptions that they mature during embryonic development.
Lipids entering the brain as a result of damage to the blood-brain barrier may be a determining cause of Alzheimer's disease. Researchers say simple lifestyle changes could reduce Alzheimer's risks by reducing the impact on the BBB and decrease Alzheimer's associated brain damage.
Researchers have created a comprehensive atlas of cell types in the brain's cerebrovascular system.
Applying rapid short pulses of ultrasound can non-invasively deliver liposomes directly to the brain, across the blood-brain barrier.
