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          blood-brain barrier

          This shows a person and a brain.
          FeaturedNeuroscience
          ·June 4, 2025·4 min read

          Aging Brain More Vulnerable to Even Mild Oxygen Deprivation

          New research shows that even mild, prolonged exposure to low oxygen levels can significantly disrupt the blood-brain barrier (BBB) in aging brains. Using mice aged 2 to 23 months, scientists found that older mice experienced 4–6 times more BBB breakdown than younger mice under similar hypoxic conditions.
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          This shows a brain.
          FeaturedGeneticsNeuroscience
          ·May 26, 2025·5 min read

          Nitrous Oxide Unlocks Blood-Brain Barrier for Safer Gene Delivery

          Researchers have discovered that nitrous oxide can safely enhance the delivery of gene therapy to the brain by making the blood-brain barrier (BBB) more permeable when paired with focused ultrasound (FUS). This method required significantly lower concentrations of microbubbles and ultrasound pressure than conventional techniques, reducing the risk of tissue damage.
          Read More
          This shows a brain.
          FeaturedGeneticsNeuroscience
          ·February 18, 2025·5 min read

          Nanoparticles Deliver mRNA to the Brain, Bypassing Blood-Brain Barrier

          Scientists have developed a lipid nanoparticle system that enables mRNA to cross the blood-brain barrier, a long-standing challenge in neuroscience. In studies using mice and human brain tissue, these nanoparticles successfully delivered therapeutic mRNA, opening doors for potential treatments for neurological diseases like Alzheimer’s, ALS, and brain cancer.
          Read More
          This shows RNA.
          FeaturedGeneticsNeuroscience
          ·December 17, 2024·6 min read

          Brain-Targeted mRNA Delivery Breaks the Blood-Brain Barrier

          Researchers have developed lipid nanoparticles (LNPs) that cross the blood-brain barrier (BBB) and precisely target brain cells, a major step toward treating neurological diseases like Alzheimer’s. By attaching short peptides to LNPs, scientists achieved targeted mRNA delivery to neurons and endothelial cells, avoiding invasive procedures. Peptides are smaller, more stable, and easier to use than antibodies, making them ideal for LNP-based therapies.
          Read More
          This shows a brain.
          FeaturedGeneticsNeurologyNeuroscience
          ·November 25, 2024·4 min read

          New Platform Overcomes Blood-Brain Barrier for Drug Delivery

          Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier.
          Read More
          This shows a brain.
          FeaturedGeneticsNeurologyNeuroscience
          ·August 5, 2024·5 min read

          Genetically Engineered Parasite Delivers Drugs to the Brain

          Researchers genetically engineered the parasite Toxoplasma gondii to deliver drugs across the blood-brain barrier. This innovative approach has been used to deliver therapeutic proteins to neurons, showing promise for treating neurological conditions like Rett syndrome. The research highlights the potential for parasites to act as delivery vehicles for large molecules that typically struggle to penetrate the brain. This breakthrough could lead to new treatments for a variety of neurological disorders.
          Read More
          This shows DNA.
          FeaturedGeneticsNeurologyNeuroscience
          ·June 28, 2024·4 min read

          New Molecular Signatures Found for Alzheimer’s Disease

          Researchers identified unique molecular signatures of blood-brain barrier dysfunction in Alzheimer's disease. They discovered altered communication between brain vascular cells mediated by VEGFA and SMAD3 molecules. These findings could lead to new diagnostic biomarkers and treatment options for Alzheimer's.
          Read More
          This shows a brain.
          FeaturedNeuroscience
          ·June 3, 2024·4 min read

          Could Your Brain Have Its Own Microbiome?

          Recent research suggests the brain might host its own microbiome, challenging the long-held belief that it is a sterile organ. Studies have found bacterial and fungal genetic material in brain tissues, particularly in those with Alzheimer’s. The brain microbiome could be linked to diseases, offering potential new treatment avenues. However, much remains unknown about how microbes enter and affect the brain.
          Read More
          This shows a virus and neurons.
          FeaturedGeneticsNeurologyNeuroscience
          ·May 16, 2024·7 min read

          Engineered Virus Crosses Blood-Brain Barrier to Deliver Gene Therapy

          Researchers have engineered a gene therapy delivery vehicle that efficiently crosses the blood-brain barrier in mice. This breakthrough uses a human protein to ferry therapeutic genes into the brain, potentially paving the way for safer and more effective treatments for various brain diseases, including neurodevelopmental and neurodegenerative disorders.
          Read More
          This shows a brain.
          Brain CancerFeaturedNeurologyNeuroscience
          ·May 6, 2024·6 min read

          Nanoparticles Penetrate Blood-Brain Barrier to Treat Cancer

          Researchers developed a novel nanoparticle that can cross the blood-brain barrier to target both primary breast tumors and brain metastases simultaneously. This dual-action approach utilizes a biodegradable polymer loaded with two prodrugs targeting cancer cell mitochondria.
          Read More
          This shows blood vessels.
          FeaturedNeuroscience
          ·April 3, 2024·3 min read

          How Brain Blood Vessels Develop

          Blood vessels in the brain develop under unique rules, challenging longstanding beliefs about vascular formation. This research identified a specific enzyme crucial for the invasion of blood vessels into the brain, linking the formation of these vessels directly with the establishment of the blood-brain barrier.
          Read More
          This shows a brain.
          FeaturedNeuroscience
          ·September 26, 2023·3 min read

          Probing E-Cig and Alcohol’s Joint Assault on the Blood-Brain Barrier

          E-cigarettes, popular among teens, have been linked to increased alcohol and drug consumption. Now, with NIH funding, researchers seeks to understand the effects of combining e-cigarettes and alcohol on our brain's protective layer: the blood brain barrier.
          Read More
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          Universally Cool: Personality Traits That Cross Cultural Lines

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          Aging Brain May Adapt to Decode Tricky Social Cues

          This shows a neuron.

          Clearing Brain Sugar Stores Could Protect Against Dementia

          This shows an elderly couple.

          Cough Medicine Shows Promise in Slowing Parkinson’s Dementia

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