blood-brain barrier

Featured Neurology Open Neuroscience Articles

·June 24, 2020

Pulse pressure: A game changer in the fight against dementia

Elevated pulse pressure in blood traveling to the brain causes inflammation, oxidative stress, and apoptosis in the blood-brain barrier that leads to brain damage. Read More

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·April 29, 2020

APOE4 triggers early breakdowns in the blood-brain barrier

APOE4, a gene implicated as a risk factor for Alzheimer's disease, triggers leaks in the blood-brain barrier. The damage to capillaries APOE4 causes correlates with increased levels of cyclophilin, a protein that causes the inflammation that is a signature of early Alzheimer's. Read More

Featured Neuroscience

·April 17, 2020

New nanocarrier drug delivery technology crosses the blood-brain barrier

Researchers have developed a cyclic peptide that can enhance blood-brain barrier penetration. Read More

Featured Neurology Neuroscience Open Neuroscience Articles

·April 10, 2020

More evidence ultrasound can help in battle against Alzheimer’s disease

Combining focused ultrasound with microbubble treatments weakens the connection between blood-brain barrier cells, effectively allowing for better delivery and absorption of drug treatments. Read More

Featured Neuroscience Psychology

·March 14, 2020

How chronic stress changes the brain, and what you can do to reverse the damage

Chronic stress can affect a person's health and mental well being. Due to the COVID-19 virus, chronic stress is on the rise worldwide. Researchers examine the general and psychological health implications of chronic stress and suggest some methods we can adopt to keep our stress levels in check. Read More

Featured Genetics Neuroscience Open Neuroscience Articles

·February 28, 2020

Our own immune cells damage the integrity of the blood-brain barrier

Microglia initially protects the blood-brain barrier from damage due to systemic inflammation. However, microglia can alter their behavior and increase the permeability of the blood-brain barrier, thus damaging it. Read More

Featured Genetics Neuroscience Psychology

·January 21, 2020

Treatment for depression must also restore proper functioning of the blood-brain barrier

In order to treat those with treatment-resistant depression, researchers suggest the integrity of the blood-brain barrier be restored. Read More

This shows the chip, a brain and neurons

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·January 4, 2020

Buzzing Through the Blood-Brain Barrier

Neuroengineers have developed a new, non-toxic, biodegradable device that can help transport vital medications to the brain by locally opening the blood-brain barrier with ultrasound. Read More

Featured Neurology Neuroscience

·December 29, 2019

Drugs that quell brain inflammation reverse dementia

Older mice given anti-inflammatory medication were better able to learn new tasks and became almost as adept at learning as mice half their age. Read More

Featured Neurology Neuroscience

·December 4, 2019

Drugs that quell brain inflammation reverse dementia

A synthesized small-molecule drug blocks the TGF-beta receptor in astrocytes and traverses the blood-brain barrier in mice. When administered, the drug lowered receptor activity to that seen in younger mice and reduced inflammation. The aged mice were able to navigate mazes and learn spatial tasks as well as younger mice. Read More

Featured Neuroscience

·October 22, 2019

Exposure to environmental PCBs impairs brain function in mice

Polychlorinated biphenyls (PCBs), chemicals commonly used during the 20th century as flame retardants and in industrial products, disrupt the performance of astrocytes, leading to impaired function. Environmental exposure to PCBs could contribute to a range of neurodegenerative diseases. Read More