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          blood-brain barrier

          This shows a neuron.
          AutismFeaturedGeneticsNeuroscience
          ·February 25, 2026·10 min read

          Overactive MicroRNA Triggers Leaky Brain in Rett Syndrome

          It’s not just the neurons. Scientists discover that Rett syndrome causes the brain’s "plumbing" to leak, disrupting the blood-brain barrier and hijacking neural activity.
          Read More
          This shows a brain.
          FeaturedNeurologyNeuroscience
          ·September 29, 2025·6 min read

          Alzheimer’s Study Finds Blood-Brain Barrier Largely Intact

          A new study suggests that the blood-brain barrier (BBB) remains intact in a widely used mouse model of Alzheimer’s disease. Using a tracer molecule and advanced analysis, scientists found no significant leakage across brain regions, even near amyloid plaques.
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          This shows neurons.
          FeaturedNeurologyNeuroscience
          ·August 12, 2025·4 min read

          Why the Blood-Brain Barrier Weakens With Age

          A new study has uncovered why the blood-brain barrier — the brain’s protective shield — becomes leakier with age, potentially triggering memory decline. Researchers identified that proteins N-cadherin and occludin, which help maintain the barrier’s tight junctions, decrease over time.
          Read More
          This shows a brain.
          FeaturedNeuroscience
          ·July 9, 2025·3 min read

          Popular Muscle Supplement Creatine Critical for Brain Function

          Creatine is well known for its role in muscle energy, but it’s also critical for brain function and development. In people with creatine deficiency disorders, supplements often fail to improve neurodevelopment because the brain’s protective barrier blocks access.
          Read More
          This shows a person and a brain.
          FeaturedNeuroscience
          ·June 4, 2025·4 min read

          Aging Brain More Vulnerable to Even Mild Oxygen Deprivation

          New research shows that even mild, prolonged exposure to low oxygen levels can significantly disrupt the blood-brain barrier (BBB) in aging brains. Using mice aged 2 to 23 months, scientists found that older mice experienced 4–6 times more BBB breakdown than younger mice under similar hypoxic conditions.
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          This shows a brain.
          FeaturedGeneticsNeuroscience
          ·May 26, 2025·5 min read

          Nitrous Oxide Unlocks Blood-Brain Barrier for Safer Gene Delivery

          Researchers have discovered that nitrous oxide can safely enhance the delivery of gene therapy to the brain by making the blood-brain barrier (BBB) more permeable when paired with focused ultrasound (FUS). This method required significantly lower concentrations of microbubbles and ultrasound pressure than conventional techniques, reducing the risk of tissue damage.
          Read More
          This shows a brain.
          FeaturedGeneticsNeuroscience
          ·February 18, 2025·5 min read

          Nanoparticles Deliver mRNA to the Brain, Bypassing Blood-Brain Barrier

          Scientists have developed a lipid nanoparticle system that enables mRNA to cross the blood-brain barrier, a long-standing challenge in neuroscience. In studies using mice and human brain tissue, these nanoparticles successfully delivered therapeutic mRNA, opening doors for potential treatments for neurological diseases like Alzheimer’s, ALS, and brain cancer.
          Read More
          This shows RNA.
          FeaturedGeneticsNeuroscience
          ·December 17, 2024·6 min read

          Brain-Targeted mRNA Delivery Breaks the Blood-Brain Barrier

          Researchers have developed lipid nanoparticles (LNPs) that cross the blood-brain barrier (BBB) and precisely target brain cells, a major step toward treating neurological diseases like Alzheimer’s. By attaching short peptides to LNPs, scientists achieved targeted mRNA delivery to neurons and endothelial cells, avoiding invasive procedures. Peptides are smaller, more stable, and easier to use than antibodies, making them ideal for LNP-based therapies.
          Read More
          This shows a brain.
          FeaturedGeneticsNeurologyNeuroscience
          ·November 25, 2024·4 min read

          New Platform Overcomes Blood-Brain Barrier for Drug Delivery

          Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier.
          Read More
          This shows a brain.
          FeaturedGeneticsNeurologyNeuroscience
          ·August 5, 2024·5 min read

          Genetically Engineered Parasite Delivers Drugs to the Brain

          Researchers genetically engineered the parasite Toxoplasma gondii to deliver drugs across the blood-brain barrier. This innovative approach has been used to deliver therapeutic proteins to neurons, showing promise for treating neurological conditions like Rett syndrome. The research highlights the potential for parasites to act as delivery vehicles for large molecules that typically struggle to penetrate the brain. This breakthrough could lead to new treatments for a variety of neurological disorders.
          Read More
          This shows DNA.
          FeaturedGeneticsNeurologyNeuroscience
          ·June 28, 2024·4 min read

          New Molecular Signatures Found for Alzheimer’s Disease

          Researchers identified unique molecular signatures of blood-brain barrier dysfunction in Alzheimer's disease. They discovered altered communication between brain vascular cells mediated by VEGFA and SMAD3 molecules. These findings could lead to new diagnostic biomarkers and treatment options for Alzheimer's.
          Read More
          This shows a brain.
          FeaturedNeuroscience
          ·June 3, 2024·4 min read

          Could Your Brain Have Its Own Microbiome?

          Recent research suggests the brain might host its own microbiome, challenging the long-held belief that it is a sterile organ. Studies have found bacterial and fungal genetic material in brain tissues, particularly in those with Alzheimer’s. The brain microbiome could be linked to diseases, offering potential new treatment avenues. However, much remains unknown about how microbes enter and affect the brain.
          Read More
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          This shows a person sleeping and leaves. Caption reads "The Truth About Cannabis and Sleep."

          Cannabis Destroys Sleep Quality

          This shows a woman and DNA. Caption reads "Is Anorexia Rooted Outside the Brain?"

          Genetic Risk for Anorexia May Begin Outside the Brain

          This shows a brain on a scale.

          Higher BMI Linked to Longer Survival After a Dementia Diagnosis

          This shows an ear and DNA. Caption reads "Phenotyping Unlocks Genetic Predictors to Detect Hearing Loss."

          Can We Predict Hearing Loss Long Before Symptoms Ever Start?

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