blood-brain barrier

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blood-brain barrier

·December 4, 2019·6 min read

Drugs that quell brain inflammation reverse dementia

A synthesized small-molecule drug blocks the TGF-beta receptor in astrocytes and traverses the blood-brain barrier in mice. When administered, the drug lowered receptor activity to that seen in younger mice and reduced inflammation. The aged mice were able to navigate mazes and learn spatial tasks as well as younger mice. Read More

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·October 22, 2019·3 min read

Exposure to environmental PCBs impairs brain function in mice

Polychlorinated biphenyls (PCBs), chemicals commonly used during the 20th century as flame retardants and in industrial products, disrupt the performance of astrocytes, leading to impaired function. Environmental exposure to PCBs could contribute to a range of neurodegenerative diseases. Read More

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·August 28, 2019·6 min read

Robotic thread is designed to slip through the brain’s blood vessels

A newly designed thread-like robot can deliver clot reducing therapies in response to stroke or other brain blockages. Read More

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·July 12, 2019·3 min read

Healthy blood vessels may be the answer to Alzheimer’s prevention

Damaged capillaries in the brain may set the stage for the development of Alzheimer's disease, years before symptoms appear. Read More

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·June 6, 2019·5 min read

Ultrasound method restores dopaminergic pathway in brain at Parkinson’s early stages

Using transcranial focused ultrasound in combination with injectable microbubbles, researchers open a pathway through the blood-brain barrier. The technique allows drugs to penetrate the brain and trigger therapeutic effects for those with neurodegenerative diseases. Read More

This shows the BBB created on the organ-chip

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·June 6, 2019·4 min read

Scientists recreate blood-brain barrier defect outside the body

Using induced pluripotent stem cells derived from patients with neurodegenerative disorders, researcher recreated the blood-brain barrier inside Organ-Chips. Read More

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·May 14, 2019·8 min read

Blocking protein curbs memory loss in old mice

Blocking VCAM1 increased neurogenesis, and reduced microglia reactivity in the hippocampus of older mice. Read More

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·April 22, 2019·8 min read

New insight into how obesity and insulin resistance can impair cognition

Adora2a mediating signaling in vascular endothelial cells disrupts the blood-brain barrier in obesity. This, researchers report, could be an underlying mechanism for synaptic plasticity and cognitive deficits in those with insulin resistance and obesity. Read More

This shows a brain with the chemical structure of cbd

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·April 17, 2019·2 min read

Cannabidiol could help deliver medications to the brain

Cannabidiol may be able to bypass the blood-brain barrier to effectively deliver medications directly to the brain. Read More

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·February 22, 2019·4 min read

How Blood Vessels Protect the Brain During Inflammation

A new study reveals how blood vessels help protect the brain during inflammation. The findings could help in the development of new treatments for neurodegenerative and autoimmune diseases. Read More

Featured Neuroscience

·February 15, 2019·1 min read

Breaks in the Blood-Brain Barrier Can Cause Brains to Get Old Before Their Time

A new study reports damage to the blood-brain barrier can cause age related cognitive decline, and sheds light on how we could reverse the aging process in the brain. Read More

Featured Neurology Neuroscience

·January 14, 2019·4 min read

Blood-Brain Barrier Breakdown an Early Driver of Dementia

A new study reports leaky capillaries in the brain may be an early sign of Alzheimer's disease as it can signal cognitive impairment prior to the buildup of proteins associated with the neurodegenerative disease. Read More

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