While patients with schizophrenia, major depressive disorder, and bipolar disorder experience a lack of motivation and anhedonia, the neural patterns of emotion-behavior dissociation differ between the disorders.
Astrocytes derived from pluripotent stem cells of bipolar patients provide suboptimal support for neural activity. The malfunction can be traced to the inflammation-promoting molecule, interleukin-6.
Combining neuroimaging data with machine learning, researchers have identified patterns of brain activation during reward anticipation, associated with an increased risk of developing bipolar disorder. The patterns of neural activation predict the severity of mania symptoms in young adults who have not yet developed the disorder.
A new neuroimaging study reveals those with bipolar depression have less activity in the amygdala and few connections with other areas of the brain than those with clinical depression.
Researchers examine the personal writings of Robert Burns, Scotland's national bard, and conclude he may have suffered from bipolar disorder.
Researchers report mitochondrial dysfunction may affect the activity of serotonergic neurons in mice with ANT1 mutations. The findings may provide insight into the origins of bipolar disorder.
Typically, many people associate depression with feelings of sadness or despair. However, depression can also affect your cognitive abilities and memory. A new paper reviews the impact depression has on cognitive function and considers therapy options to help improve these often overlooked symptoms of the disorder.
Researchers have identified a range of psychiatric disorders, including schizophrenia and autism, that share physical characteristics at the molecular level. Specifically, the study identifies common patterns of neural gene expression. In addition, researchers note important differences in gene expression that distinguish the disorders.
Following a 12 year long study, researchers have identified seven phenoclasses that can help doctors to diagnose and track the progression of bipolar disorder in patients.