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Alzheimer’s disease

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Featured Neurology Neuroscience Psychology

·April 19, 2022·9 min read

Artificial Intelligence to Assess Dementia Risk and Enhance the Effectiveness of Depression Treatments

Using MEG data, a new AI algorithm called AI-MIND is able to assess dementia risk and the potential effectiveness of treatments for depression, researchers say.

Featured Genetics Neurology Neuroscience

·April 19, 2022·4 min read

Age and Alzheimer’s Related Brain Decline Linked to Little-Studied Enzyme

The HDAC9 enzyme appears to play a critical role in learning and neural communication. Decreased expression of HDAC9 in the hippocampus and prefrontal cortex has been noted in patients with Alzheimer's disease. Researchers say HDAC9 may be a regulator of synaptic plasticity.

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Featured Neurology Neuroscience Open Neuroscience Articles Psychology

·April 19, 2022·4 min read

Psychiatric Symptoms in Alzheimer’s Disease

Like cognitive deficits, psychiatric symptoms such as depression, apathy, and anxiety associated with Alzheimer's disease appear to be a direct consequence of underlying brain changes as a result of increased amyloid-beta accumulation.

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Featured Neurology Neuroscience

·April 14, 2022·4 min read

Sense of Purpose Is Linked to Reduced Risk of Dementia

Living life with a sense of purpose was associated with a reduced risk of developing Alzheimer's disease and other dementias later in life. Researchers found a sense of purpose was associated with a 19% reduced rate of clinically significant cognitive impairment.

Featured Neurology Neuroscience Open Neuroscience Articles

·April 14, 2022·5 min read

Key Signaling Pathway in Immune Cells Could Be New Alzheimer’s Target

Tau-tangles trigger the inflammatory activation of microglia via the NF-κB pathway. Inhibiting the microglia NF-κB signaling pulled the immune cells out of their inflammatory state and reversed learning and memory problems in tau-based Alzheimer's mouse models.

Featured Neurology Neuroscience

·April 14, 2022·6 min read

Healthy Lifestyle Associated With More Years Without Alzheimer’s

Older adults who lived a healthier lifestyle not only added years to their life expectancy, they also had a decreased risk of Alzheimer's disease.

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Featured Genetics Neurology Neuroscience

·April 13, 2022·5 min read

Novel Root Cause of Tau-Induced Neurodegeneration Discovered

mRNA decay may facilitate tau-induced damage to the brain and associated apoptosis that contributes to a range of neurodegenerative disorders. Researchers found the mechanism can be altered pharmacologically, providing a new target for the development of therapeutics to prevent or slow the progression of some neurodegenerative disorders.

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Featured Neurology Neuroscience

·April 8, 2022·5 min read

Alzheimer’s Brain Barrier Damage Theory Could Pave Way for New Treatments

Lipids entering the brain as a result of damage to the blood-brain barrier may be a determining cause of Alzheimer's disease. Researchers say simple lifestyle changes could reduce Alzheimer's risks by reducing the impact on the BBB and decrease Alzheimer's associated brain damage.

Featured Neurology Neuroscience

·April 5, 2022·3 min read

Vitamin K May Help Ward Off Dementia

Vitamin K could help reduce or prevent age-related cognitive decline associated with Alzheimer's and other dementias, a new rat study reveals.

Featured Genetics Neurology Neuroscience

·April 5, 2022·3 min read

Genetic ‘Hotspots’ That Speed up and Slow Down Brain Aging Could Provide New Targets for Alzheimer’s Drugs

15 newly discovered "hotspots" in the genome that either speed up or slow down brain aging could be new targets for the development of Alzheimer's medications and therapies for other brain disorders.

Featured Neurology Neuroscience

·April 4, 2022·7 min read

Loss of Neurons, Not Lack of Sleep, Makes Alzheimer’s Patients Drowsy

Degeneration of neurons associated with wakefulness, and not a lack of sleep, makes Alzheimer's patients more drowsy. The degeneration of these neurons is caused by the tau protein. In PSP, the damage to the neurons was associated with symptoms of sleep deprivation.

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Featured Genetics Neurology Neuroscience

·April 4, 2022·6 min read

Alzheimer’s Disease: The Identification of 75 Genetic Risk Factors Brings New Insights

Researchers have identified 75 regions of the genome associated with Alzheimer's disease, including 42 novel regions. The findings shed new light on the biological mechanisms of Alzheimer's and provide a new avenue for the treatment of this neurodegenerative disorder.