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Alzheimer’s disease

Featured Genetics Neurology Neuroscience

·November 18, 2024·4 min read

Unique Brain Plaques Linked to Alzheimer’s Mutation Decoded

Researchers have identified the structure of amyloid beta fibrils linked to a rare inherited form of Alzheimer’s disease caused by the Arctic mutation. Using cryo-electron microscopy and NMR, they revealed a W-shaped fibril structure that explains the formation of cottonwool plaques—large, spherical brain structures unique to this mutation.

Featured Genetics Neurology Neuroscience

·November 16, 2024·8 min read

Alzheimer’s Linked to Key Proteins via Cerebrospinal Fluid Analysis

Using cerebrospinal fluid from living patients, researchers have identified specific proteins and genetic pathways involved in the development and progression of Alzheimer’s disease. This proteomic analysis revealed 38 proteins likely to play causal roles in Alzheimer’s, 15 of which are potential drug targets.

Featured Neurology Neuroscience

·November 12, 2024·5 min read

Frailty Boosts Dementia Risk

Frailty is a strong predictor of dementia risk, with risk increasing by 40% with each 4-5 additional age-related health conditions. This connection between frailty and dementia suggests that frailty may not simply result from undetected dementia but actively contributes to its onset.

Featured Neurology Neuroscience

·November 11, 2024·6 min read

Fluctuating Cholesterol Linked to Higher Dementia Risk

Older adults with significant fluctuations in cholesterol levels are at increased risk for dementia and cognitive decline, even without medication changes. Researchers studied nearly 10,000 older adults, tracking their cholesterol levels and cognitive function over six years. High variability in total and LDL ("bad") cholesterol was associated with a 60% increase in dementia and 23% increase in cognitive decline.

Featured Genetics Neurology Neuroscience

·November 11, 2024·4 min read

Targeting Enzyme TYK2 Could Reduce Tau in Alzheimer’s Disease

Scientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key feature of Alzheimer’s disease and related dementias. By reducing TYK2 activity in animal models, researchers found tau buildup was decreased, suggesting TYK2 inhibitors could be a potential therapeutic pathway.

Featured Neurology Neuroscience

·November 7, 2024·4 min read

New Nasal Spray Could Delay Alzheimer’s Progression by Years

Researchers have developed a promising nasal spray therapy targeting neuroinflammation in Alzheimer’s disease, potentially delaying its progression by over a decade. Using extracellular vesicles derived from neural stem cells, the treatment reduced inflammation and protein build-up in the brain in early-stage Alzheimer’s animal models.

This shows a man's face and broken bottles.

Featured Genetics Neurology Neuroscience

·November 5, 2024·5 min read

Gene Study Links Alcohol Addiction to Accelerated Alzheimer’s Progression

Researchers discovered alcohol use disorder (AUD) and Alzheimer's disease (AD) exhibit similar patterns of gene dysregulation, hinting that alcohol consumption may hasten Alzheimer’s progression. By analyzing gene expression across individual brain cells, the team found shared disruptions in inflammation, cell signaling, and blood vessel functions in both disorders.

Featured Neurology Neuroscience

·October 31, 2024·7 min read

New Clues on Protein Fibrils Could Transform Alzheimer’s Research

A recent study reveals that a polymer called polyphosphate may stabilize fibrils, protein structures linked to Alzheimer's, Parkinson's, and other neurodegenerative diseases. Researchers used computer models to show that polyphosphate fits a previously unidentified "mystery density" in these fibrils, suggesting it plays a protective role. While the findings could eventually inform therapies, more research is needed to understand polyphosphate's exact role in the brain.

Featured Neurology Neuroscience

·October 25, 2024·4 min read

Pausing Amyloid Fibrils Offers New Alzheimer’s Insight

Researchers have identified a unique “paused state” in the growth of amyloid β fibrils, linked to Alzheimer’s disease, using high-speed atomic force microscopy. In this state, fibril growth is halted, allowing an antibody, 4396C, to bind and prevent further growth, opening a potential path to slow Alzheimer’s progression.

Featured Neurology Neuroscience

·October 24, 2024·4 min read

Ozempic Shows Potential in Lowering Alzheimer’s Risk

New research suggests that semaglutide, a popular diabetes and weight-loss drug, may reduce the risk of Alzheimer’s disease in people with type 2 diabetes. The study compared semaglutide to seven other anti-diabetic drugs and found it was linked to a significantly lower risk of developing Alzheimer’s.

Featured Neurology Neuroscience

·October 24, 2024·4 min read

Gut Bacteria Linked to Alzheimer’s Progression

Researchers have discovered that the gut bacteria Klebsiella pneumoniae can migrate to the brain, leading to inflammation and cognitive decline that mimic Alzheimer’s symptoms. The study suggests that hospital-acquired infections combined with disrupted gut microbiomes may increase the risk of developing neurodegenerative diseases.

Featured Neurology Neuroscience

·October 22, 2024·4 min read

Bilingualism Boosts Brain Resilience, Delaying Alzheimer’s Onset

Bilingualism has been shown to delay the onset of Alzheimer’s disease by up to five years. A new study reveals that bilingual individuals with Alzheimer’s have larger hippocampi, a critical brain region for memory, compared to monolinguals.

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Alzheimer’s disease

Unique Brain Plaques Linked to Alzheimer’s Mutation Decoded

Alzheimer’s Linked to Key Proteins via Cerebrospinal Fluid Analysis

Frailty Boosts Dementia Risk

Fluctuating Cholesterol Linked to Higher Dementia Risk

Targeting Enzyme TYK2 Could Reduce Tau in Alzheimer’s Disease

New Nasal Spray Could Delay Alzheimer’s Progression by Years

Gene Study Links Alcohol Addiction to Accelerated Alzheimer’s Progression

New Clues on Protein Fibrils Could Transform Alzheimer’s Research

Pausing Amyloid Fibrils Offers New Alzheimer’s Insight

Ozempic Shows Potential in Lowering Alzheimer’s Risk

Gut Bacteria Linked to Alzheimer’s Progression

Bilingualism Boosts Brain Resilience, Delaying Alzheimer’s Onset

AI Chip Mimicking Brain’s Reflex Center Developed

Study Overturns Decades of External Axon Growth Theory

Study Shatters Assumptions About Brain Connectome Dynamics

Earliest Evidence of Right-Handedness Found

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