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Alzheimer’s disease

·August 30, 2024·5 min read

Tau May Protect Brain Cells from Oxidative Damage

Researchers have discovered that the Tau protein, often linked to neurodegenerative diseases like Alzheimer's, also has a protective role in the brain. Tau helps combat oxidative stress by aiding in the formation of lipid droplets in glial cells, which sequester toxic lipids and protect neurons.

This shows a person holding a brain model.

Featured Neurology Neuroscience

·August 25, 2024·6 min read

Blocking a Brain Pathway Reverses Memory Loss in Alzheimer’s

Blocking the kynurenine pathway, a regulator of brain metabolism, can restore cognitive function in lab mice with Alzheimer’s disease. The pathway is overactivated in Alzheimer’s, disrupting glucose metabolism and starving neurons of energy. By inhibiting this pathway, researchers improved memory and brain plasticity in mice, offering hope for new treatments in humans. IDO1 inhibitors, currently in cancer trials, could be repurposed for Alzheimer’s treatment.

Featured Neurology Neuroscience

·August 23, 2024·5 min read

Does Multiple Sclerosis Lower Dementia Risk?

Research has revealed that individuals with multiple sclerosis (MS) are significantly less likely to exhibit the molecular signs of Alzheimer’s disease, suggesting a protective element in MS that could inspire new Alzheimer's treatments. The study found that MS patients had 50% less amyloid plaque accumulation, a key indicator of Alzheimer’s, compared to non-MS individuals. This connection between MS and reduced Alzheimer's risk highlights potential immune-related mechanisms that may be leveraged for therapeutic strategies.

Featured Neurology Neuroscience

·August 12, 2024·4 min read

Glial Cells Play Key Role in Alzheimer’s Development

New research reveals that glial cells, specifically oligodendrocytes, produce amyloid beta, a protein linked to Alzheimer’s disease, challenging the long-held belief that neurons are the sole contributors. This discovery opens new possibilities for therapies aimed at preventing plaque formation in the brain. Targeting both neurons and glial cells could slow the disease’s progression by inhibiting amyloid beta production before plaques form.

Featured Genetics Neurology Neuroscience

·August 8, 2024·5 min read

Parental Alcohol Use Linked to Early Aging in Kids

Children of parents with alcohol use disorders inherit early aging symptoms, including high cholesterol, heart problems, arthritis, and early-onset dementia. This effect is worse if both parents have alcohol issues, especially in male offspring, due to mitochondrial dysfunction inherited from parents. Researchers suggest that improving mitochondrial health through exercise and vitamin intake could help delay these effects.

Featured Neurology Neuroscience

·August 8, 2024·8 min read

Light and Sound Therapy Maintains Myelin in Alzheimer’s

A new study finds that 40Hz light and sound therapy helps maintain myelin, a crucial brain structure, in Alzheimer's patients. This therapy, which protects neurons and supports brain function, could offer new treatment avenues for neurodegenerative diseases. Researchers discovered that this stimulation enhances neural connections and reduces harmful inflammation. The therapy also shows potential for treating other conditions involving myelin loss, such as multiple sclerosis.

Featured Neurology Neuroscience

·August 6, 2024·5 min read

Dopamine Treatment Reduces Alzheimer’s Plaques

Researchers uncovered a promising approach to treating Alzheimer’s disease by using dopamine to enhance brain enzyme activity that reduces harmful plaques. Conducted on mice, the study shows that dopamine increases neprilysin production, which breaks down beta-amyloid plaques linked to Alzheimer's.

Featured Genetics Neurology Neuroscience

·August 1, 2024·8 min read

Skin Cells Turned Neurons Reveal Alzheimer’s Aging Effects

Researchers have developed a method to transform skin cells into brain neurons, capturing the aging effects crucial for studying late-onset Alzheimer's disease. This technique accurately mimics Alzheimer's hallmarks, like amyloid beta buildup, in lab-derived neurons, allowing for detailed analysis.

This shows a child playing with her grandpa.

Featured Neurology Neuroscience

·July 31, 2024·9 min read

Intervention From Childhood Reduces Dementia Risks

A new report highlights that addressing 14 modifiable risk factors from childhood could prevent or delay nearly half of dementia cases. The study identifies high LDL cholesterol and untreated vision loss as new significant risks. Implementing early interventions can improve cognitive health and reduce the burden of dementia globally. Researchers emphasize the importance of targeted policies and lifestyle changes to mitigate these risks.

Featured Neurology Neuroscience

·July 30, 2024·6 min read

MRI Scan Predicts Alzheimer’s Risk Before Symptoms Appear

A novel study finds that specialized MRI scans can detect early brain changes that indicate a higher risk for Alzheimer’s disease (AD) before significant cognitive decline occurs. Researchers discovered that cortical microstructural changes in the brain closely resemble patterns seen in AD pathology.

Featured Neurology Neuroscience

·July 30, 2024·4 min read

GLP-1 Drug Slows Alzheimer’s Cognitive Decline

A recent study suggests that a GLP-1 drug, liraglutide, may protect the brains of people with mild Alzheimer’s disease, slowing cognitive decline by 18% over one year. This effect is likely due to the drug’s ability to reduce brain inflammation, improve insulin resistance, and lower the impact of Alzheimer’s biomarkers.

Featured Neurology Neuroscience

·July 24, 2024·9 min read

Neural Vulnerabilities and Resilience in Alzheimer’s Explored

Researchers uncover how specific brain cells and circuits become vulnerable in Alzheimer's disease and identify factors that may promote resilience to cognitive decline. Analyzing gene expression in over 1.3 million cells across multiple brain regions, the study highlights the role of Reelin in neuron protection and choline metabolism in astrocytes for cognitive resilience. These findings pave the way for potential therapeutic targets to sustain cognition and memory amid Alzheimer’s pathology.

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Alzheimer’s disease

Tau May Protect Brain Cells from Oxidative Damage

Blocking a Brain Pathway Reverses Memory Loss in Alzheimer’s

Does Multiple Sclerosis Lower Dementia Risk?

Glial Cells Play Key Role in Alzheimer’s Development

Parental Alcohol Use Linked to Early Aging in Kids

Light and Sound Therapy Maintains Myelin in Alzheimer’s

Dopamine Treatment Reduces Alzheimer’s Plaques

Skin Cells Turned Neurons Reveal Alzheimer’s Aging Effects

Intervention From Childhood Reduces Dementia Risks

MRI Scan Predicts Alzheimer’s Risk Before Symptoms Appear

GLP-1 Drug Slows Alzheimer’s Cognitive Decline

Neural Vulnerabilities and Resilience in Alzheimer’s Explored

Ultra-Processed Foods Erodes Visual Attention

Why Feeling Good is Harder than Not Feeling Bad

Astrocytes Identified as Key Target for Treating Fragile X Syndrome

Liver Talks to the Brain to Control Appetite

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