Blocking hippocampal STAT3 in those with alcohol use disorder may alleviate symptoms of depression associated with withdrawal.
A new study reveals sex differences in the way those with alcohol use disorder process facial emotions. Men with AUD showed greater activation in frontal brain areas when processing facial emotions. The increased activation was not seen in women with AUD.
A new series of studies review the roles neuroplasticity and neurogenesis play in alcohol addiction and recovery.
Researchers have identified a pathway in the brain responsible for the development of alcohol addiction.
People who are most sensitive to the pleasurable and rewarding effects of alcohol are at greater risk of developing alcohol use disorders.
Manipulating memory via optogenetics mitigated addiction-related behaviors.
Low-level exposure to lead during development does not lead to alcohol use disorder, but does alter the neural circuits in a way that if addiction occurs, it makes it harder to refrain from returning to addiction related behaviors.
Study reveals binge drinking is associated with more widespread neural dysfunction than previously believed. In those who binge drink, the visual areas of the brain show unusually high levels of activation. Additionally, those who binge drink have more difficulty in feeling empathy for others.
Researchers hypothesize vitamin B1 (thiamine) deficiency may play a significant role in dementia associated with alcohol use disorder. It is known iron deposits in the brain contribute to neurodegenerative diseases. Those with AUD have elevated levels of both iron in their blood and thiamine deficiency. Thiamine is vital for maintaining the blood-brain barrier. Thiamine deficiency associated with AUD disrupts the integrity of the BBB, allowing for more iron deposits within the brain and leading to oxidative tissue damage.
Study reveals a previously unrecognized family connection to alcohol use disorder, the drinking habits of a person's in-laws. People married to those who experienced parental alcohol misuse as a child are more likely to develop an addiction to alcohol, even if the spouse has no history of a personal battle with alcohol use.
Twenty-nine genes have now been identified as being linked to problematic alcohol use. A new study report, in addition to an increased risk of alcohol use disorder, people with specific genes linked to AUD also have an increased risk of depression, insomnia, and addiction to tobacco.
Estrogen level fluctuations appear to play a role in alcohol use disorder in women. Reducing the number of estrogen receptors in the ventral tegmental area decreased binge drinking behaviors in female mouse models.
