Why Moms Take Risks to Protect Their Infants

Summary: A mother’s overwhelming desire to take risks in the face of danger to protect her child, and other nurturing behaviors, are driven by neurons in the cMPOA region of the hypothalamus which contains a protein called the calcitonin receptor.

Source: RIKEN

It might seem like a given that mothers take extra risks to protect their children, but have you ever wondered why?

A new study led by Kumi Kuroda at the RIKEN Center for Brain Science (CBS) in Japan shows that in mice, this and other nurturing behaviors are driven in part by neurons in a small part of the forebrain that contain a protein called the calcitonin receptor.

The study was published in Cell Reports.

Many simple behaviors, such as eating and drinking, are driven by different parts of the brain’s hypothalamus. The new study focused on identifying the part that drives a much more complicated behavior: caring for infants. As Kuroda explains, “we were able to narrow down the brain cells necessary for parental and non-parental care in mice to a subset of neurons in the central MPOA region that contain the calcitonin receptor.”

The team’s previous research pointed to the central MPOA (cMPOA) region of the hypothalamus as the hub of nurturing behavior. This part of the brain contains more than seven different kinds of neurons, and the goal of the new study was to find a marker for the ones which are the most important for nurturing.

The researchers visualized 20 candidate genes in the cMPOA of nurturing mice together with a marker for active neurons. Double labeling was highest for the calcitonin receptor gene, making it the most likely marker for nurturing-related neurons.

Next, the researchers examined these neurons in detail. There were three major findings.

First, the number of cMPOA neurons with the calcitonin receptor was higher in post-partum mothers than in virgin females, males, or fathers.

Second, incoming and outgoing connections to these neurons from other parts of the brain changed in females after they gave birth.

Third, silencing these neurons completely disrupted nurturing behavior.

Nurturing behaviors in mice include nest building, hovering over pups in the nest, and picking pups up and bringing them back to the nest — termed pup retrieval. After the critical neurons were silenced, virgin females left pups scattered around the cage, even after mating and birthing their own pups.

Other behaviors such as nursing and nest building were also affected, and the mothers acted overall as if they had little motivation for nurturing behavior. As a result, many pups could not survive without intervention.

After establishing that cMPOA neurons expressing the calcitonin receptor are necessary for nurturing, the researchers hypothesized that the receptor itself has a special function in generating the enhanced motivation for nurturing observed in mothers.

This shows a rat in a maze
The elevated pup-retrieval test was used to assess the willingness of mice to care for infants in risky/dangerous situations. See the accompanying video for the results. Credit: RIKEN

To test this hypothesis, the team devised a new pup retrieval test. Instead of placing the pups around the edges of their home cage, they placed them on an elevated maze. Being out in the arms of the elevated maze is a little unpleasant and scary for mice.

Virgin females that would retrieve pups in the cage refused to do it in the elevated maze. In contrast, mother mice always retrieved the pups, showing that their drive to nurture was greater. However, when calcitonin receptor levels were reduced by about half, even mother mice hesitated and took much longer to complete the retrievals.

“Parents, both human and animal, must choose to sacrifice one behavior for another in order to care for their children,” says Kuroda. “We found that upregulation of the calcitonin receptor is like a push in the brain that motivates mice to care for their pups, suppressing their self-interest and tendency to avoid risky and unpleasant situations.”

“The next step is to examine calcitonin receptor-expressing cMPOA neuron’s role in the nurturing behavior of non-human primates, which should be more similar to what happens in humans.”

About this neuroscience research news

Source: RIKEN
Contact: Adam Phillips – RIKEN
Image: The image is credited to RIKEN

Original Research: Open access.
Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care” by Kuroda et al. Cell Reports


Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care


  • Calcitonin receptor and its ligand amylin are expressed in the medial preoptic area
  • Calcitonin receptor + neurons are essential for maternal and alloparental care
  • Both calcitonin receptor and amylin are upregulated in postpartum mother mice
  • Calcitonin receptor upregulation takes part in risk-taking maternal behavior


Maternal mammals exhibit heightened motivation to care for offspring, but the underlying neuromolecular mechanisms have yet to be clarified.

Here, we report that the calcitonin receptor (Calcr) and its ligand amylin are expressed in distinct neuronal populations in the medial preoptic area (MPOA) and are upregulated in mothers. Calcr+ MPOA neurons activated by parental care project to somatomotor and monoaminergic brainstem nuclei.

Retrograde monosynaptic tracing reveals that significant modification of afferents to Calcr+ neurons occurs in mothers. Knockdown of either Calcr or amylin gene expression hampers risk-taking maternal care, and specific silencing of Calcr+ MPOA neurons inhibits nurturing behaviors, while pharmacogenetic activation prevents infanticide in virgin males.

These data indicate that Calcr+ MPOA neurons are required for both maternal and allomaternal nurturing behaviors and that upregulation of amylin-Calcr signaling in the MPOA at least partially mediates risk-taking maternal care, possibly via modified connectomics of Calcr+ neurons postpartum.

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