In mice, the failed epigenetic suppression of Xist leads to fetal developmental abnormalities and miscarriage. Knocking out the Xist gene greatly reduced prenatal death. The findings have implications for understanding infertility and developing new treatments to prevent miscarriage.
Learning consolidation that occurs during sleep is a result of the learning process, and is not simply due to neural processes and brain regions associated with learning.
Researchers have uncovered neural circuitry that allows the CA1 region of the hippocampus to communicate with its counterpart in the opposite hemisphere despite there being no connection between them.
Contact-seeking behavior in mice is driven by amylin peptide in the medial preoptic area of the forebrain.
Study reveals how the CA2 region of the hippocampus plays a key role in long-term memory consolidation.
In mice, natural melatonin is linked to a pre-hibernation state, allowing for a slower metabolism and survival when food is scarce or the temperature is too cold.
A mother's overwhelming desire to take risks in the face of danger to protect her child, and other nurturing behaviors, are driven by neurons in the cMPOA region of the hypothalamus which contains a protein called the calcitonin receptor.
Fenofibrate, a drug developed to control cholesterol, alleviated brain and behavioral abnormalities in mouse models of schizophrenia.
A specialized area of the mouse brain called the SuM specializes in detecting novel experiences. Within this brain area, responses to social novelty, or experiences related to unknown individuals, were segregated from those related to unfamiliar places, before being sent to areas of the brain associated with memory.