Machine learning decodes genetic influence over behavior

Summary: Machine learning is helping researchers uncover the genetic influence on foraging behaviors in mice.

Source: University of Utah Health

Mice scurry around while foraging for food, but genetics may be the unseen hand controlling these meandering movements. Researchers at University of Utah Health are using machine learning to draw links between genetic controls that shape incremental steps of instinctive and learned behaviors. The results are available online in Cell Reports on August 13.

“Patterns of complex behavior, like searching for food, are composed of sequences that feel random, spontaneous and free,” said Christopher Gregg, Ph.D., assistant professor in Neurobiology and Anatomy at U of U Health and senior author of the study. “Using machine learning, we are finding discrete sequences that are reproduced more frequently than you would expect by chance and these sequences are rooted in biology.”

The research team is venturing into the new territory of behavioral sequencing.

“We are trying to understand the architecture of complex behavior and how genetics shape these patterns,” said Gregg.

The research supports the idea that complex behavior is composed of a collection of finite ‘building blocks’ the authors call behavioral modules, and that genetics are controlling the progression of these building blocks to form different behavioral patterns.

The research team evaluated 190 mice with differences in their genetics and age as they moved from their home into a uniquely created ‘arena’ to evaluate the set of behavioral sequences expressed while foraging for food. In the search for food, mice exhibit behaviors that require many neural systems to control seeking-behaviors, anxiety, reward, preservation, hunger, satiety, attention, navigation and memory. The new methods revealed that different genetic and age effects influence different sequences.

“Most species have a home range and their behaviors are structured around this home range,” Gregg said. “We were able to identify reproduceable behavioral sequences and use this information to understand the complex patterns over time.”

The team separated round trips from home to a food source and back into a series of more than 5,600 mouse actions. Layered within these actions are additional information, such as gait pattern, velocity, distance traveled and locations visited. Using machine learning, they evaluated this information and identified 71 reproduceable behavioral sequences that are the underlying building blocks for more complex behavior patterns.

The transition from one ‘building block’ to the next implies a mechanistic relationship that yields specific foraging behaviors that minimize predation risk, energy expenditure and caloric intake. In addition, the algorithm was able to identify spontaneous responses that are unique to specific mice.

This shows a mouse on a map

Genetics control behavioral sequences that are building blocks for complex behavior patterns that shape risk, reward and effort. Hörndli et al. explore the architecture of complex behavior patterns by studying foraging in mice. They develop methods to deconstruct foraging into reproducible behavioral sequences called “modules”. Module frequency, timing and order are under genetic control. The image is credited to Cornelia N. Stacher Hörndli.

Gregg believes this approach is sensitive enough to pick up a mutation in the copy of one gene. To prove this point, his team focused on foraging behaviors in mice with a mutation in an imprinted gene, Magel2, which is linked to autism. For example, when the mother’s copy is turned off, the father’s copy is turned on. In this scenario, it was widely believed that the mother’s copy was silent and did not affect the offspring. Not so.

“What was exciting to us was we were able to detect significant effects on behavior from a single mutation in only the mother’s gene copy,” Gregg said.

At this time, the study has only explored the building blocks of foraging behavior in lab mice. Gregg believes the methodology could be applied to understand the basis of other complex behavior patterns and learn the specific genomic elements that shape behaviors leading to disease in humans, including obesity, addiction, fear, anxiety and psychiatric disorders.

“By deconstructing really complex, seemingly spontaneous behaviors, we were able to detect things that weren’t observable in other studies,” Gregg said. “If there is a mutation that causes disease in people we hope to use this method to map it to specific modules [aka behavior building blocks] to learn how genes contribute to shaping particular behavior patterns.”

Gregg was joined by Cornelia Hörndli, Eleanor Wong, Elliott Ferris, Kathleen Bennett, Susan Steinwand, Alexis Rhodes and P. Thomas Fletcher on the paper, titled Complex Economic Behavior Patterns Are Constructed from Finite, Genetically Controlled Modules of Behavior.

Funding: The work received support from the Swiss National Science Foundation, the National Institutes of Health and the New York Stem Cell Foundation.

About this neuroscience research article

Source:
University of Utah Health
Media Contacts:
Julie Kiefer – University of Utah Health
Image Source:
The image is credited to Cornelia N. Stacher Hörndli.

Original Research: Open access
“Complex Economic Behavior Patterns Are Constructed from Finite, Genetically Controlled Modules of Behavior”. Cornelia N. Stacher Hörndli et al.
Cell Reports. doi:10.1016/j.celrep.2019.07.038

Abstract

Complex Economic Behavior Patterns Are Constructed from Finite, Genetically Controlled Modules of Behavior

Highlights

• A methodology to dissect the architecture of complex behavior patterns
• Foraging patterns are built from finite, genetically controlled modules of behavior
• Different modules are linked to different economic behavior patterns
• Parental alleles of the Prader-Willi syndrome gene Magel2 regulate distinct modules

Summary
Complex ethological behaviors could be constructed from finite modules that are reproducible functional units of behavior. Here, we test this idea for foraging and develop methods to dissect rich behavior patterns in mice. We uncover discrete modules of foraging behavior reproducible across different strains and ages, as well as nonmodular behavioral sequences. Modules differ in terms of form, expression frequency, and expression timing and are expressed in a probabilistically determined order. Modules shape economic patterns of feeding, exposure, activity, and perseveration responses. The modular architecture of foraging changes developmentally, and different developmental, genetic, and parental effects are found to shape the expression of specific modules. Dissecting modules from complex patterns is powerful for phenotype analysis. We discover that both parental alleles of the imprinted Prader-Willi syndrome gene Magel2 are functional in mice but regulate different modules. Our study found that complex economic patterns are built from finite, genetically controlled modules.

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