Summary: Decriminalizing cannabis or using tightly controlled legal frameworks does not increase use. However, the fully commercialized, for-profit legal markets seen in the US and Canada drive increased health risks, higher product potency, and elevated rates of addiction and psychosis admissions. Additionally, an analysis of 54 clinical trials found little strong evidence that medical cannabinoids effectively treat primary psychiatric disorders like anxiety, PTSD, or depression.
Key Facts
- Framework Matters Most: Decriminalizing possession or implementing strict state-controlled access (limiting potency and market scale) shows virtually no evidence of increasing population-level cannabis use.
- Commercialization Drives Addiction: Large-scale for-profit legal markets in the US and Canada have escalated product potency, resulting in surging addiction rates where daily cannabis consumers now outnumber daily alcohol consumers in the US.
- Psychiatric Consequences: Commercial legal landscapes correlate with a marked rise in emergency hospital admissions for psychosis, especially cases where severe psychotic disorders manifest alongside cannabis use disorder.
- Equity & Justice Shifts: The study highlights that shifting from criminal enforcement to healthcare models via decriminalization can alleviate the racially disproportionate policing historically concentrated in Black communities.
- Weak Medical Efficacy Evidence: An analysis of 54 clinical trials revealed medical cannabinoids provide only modest benefits for insomnia and specific autism traits, but show no meaningful effectiveness for anxiety, PTSD, depression, or opioid dependence.
Source: University of Bath
Removing criminal penalties for possessing cannabis for personal use, or introducing tightly controlled legalisation of cannabis, does not appear to increase levels of cannabis use.
However, the commercial sale of cannabis is linked to increased health risks, with large-scale for-profit markets – such as those seen in the US and Canada – resulting in more potent products and higher rates of addiction.
These findings are reported in a study published on Wednesday, June 17, in The Lancet Psychiatry led by experts in addiction and mental health at the University of Bath in the UK, together with an international team from the Americas, Europe, Africa, Australia, New Zealand and Asia.
Co-authors Professor Tom Freeman, and Dr Rachel Lees Thorne, both from the Department of Psychology at Bath, say their findings highlight the distinct effects of different policy approaches globally.
Evolving policies around the world
Cannabis policies are rapidly evolving worldwide. Today, they range from strict prohibition to fully commercialised legalisation. The new paper examines global changes in cannabis policy between 2000 and 2025, and how these are linked to changes in cannabis use, cannabis addiction and other psychiatric disorders.
In the UK, cannabis is a Class B controlled drug, with a maximum penalty for possession of up to five years in prison, an unlimited fine, or both. A 2025 report by the London Drugs Commission, commissioned by London Mayor Sadiq Khan, titled The Cannabis Conundrum: a way forward for London, proposed decriminalising possession of cannabis for recreational use.
Such a change could shift the focus from managing cannabis through criminal law enforcement to healthcare, and address the disproportionate level of cannabis policing found in black communities. The findings of this new global analysis indicated that when other countries had decriminalised cannabis, there was little evidence for changes in cannabis use.
Other countries have gone a step further by legalising cannabis. The first country in the world to do this was Uruguay, which today has a tightly controlled approach where adults can access a restricted range of cannabis products from pharmacies (with limits on their potency) as well as cannabis social clubs, or by growing cannabis themselves.
In Uruguay, along with other contexts in which cannabis legalisation is tightly controlled, there is little evidence of changes in cannabis use.
By contrast, in many US states and in Canada, cannabis is legally sold through well-established, for-profit markets, making cannabis widely available. In these commercialised legal markets, use of the drug has increased. Cannabis potency has also increased since the legalisation of commercial sales, along with rates of addiction among adults, characterised by people struggling to stop using the drug despite negative effects on daily life.
Professor Freeman said: “In a rapidly changing global cannabis policy landscape it is increasingly important to ask how policy will change, rather than if it will change at all. The type of policy change is critical.
“We found little evidence for changes in use after decriminalisation or tightly controlled legalisation. By contrast, in Canada and the US, policy changes have been more substantial through commercialised legalisation, which have increased sales and consumption.
“There are now more daily consumers of cannabis than daily consumers of alcohol in the US. What followed commercialised legalisation was a rise in cannabis addiction as well as increases in hospital admissions for psychosis, including cases where psychotic disorders occurred alongside cannabis addiction.
“The emergence of a for-profit cannabis industry can result in commercial interests being prioritised over public health – just as we have seen with the alcohol and tobacco industries. Increased availability of cannabis products, greater product strength and active marketing of these products can increase the risk of harm.
“Alternative policies – such as decriminalisation or strictly regulated legalisation – can remove the harms of criminalising people who use cannabis, while limiting changes in use.”
Medical cannabis
The researchers found that poorly regulated access to medical cannabis, particularly in the absence of clear evidence on its safety and effectiveness, may also increase the risk of harm to people’s health.
The Advisory Council on the Misuse of Drugs is currently reviewing evidence on the impact of the UK’s 2018 legalisation of medical cannabis, including whether it has achieved its desired aims and whether there have been unintended consequences.
Professor Freeman said: “As global cannabis policies continue to evolve, we need to do more to track their impact – particularly in countries outside of the US and Canada, where fewer studies are conducted.”
The new review is part of a collection of papers on cannabis published in The Lancet Psychiatry and led by the University of Bath in collaboration with international partners.
Cannabis products and mental illness
The second review finds evidence that daily cannabis use can act with other risk factors to increase the risk of psychosis, but its role in depression, anxiety and risk of suicidal thoughts or suicide was less clear.
The third paper synthesises evidence from clinical trials into the use of medical cannabinoids (the active ingredients in cannabis) for the treatment of psychiatric disorders.
Though there is a growing trend to prescribe these substances to treat mental health and substance use disorders, the researchers found little strong evidence of their effectiveness on the basis of the available evidence from clinical trials.
Across 54 trials, limited benefits were found: cannabinoids modestly reduced cannabis withdrawal and use, improved sleep in insomnia, and helped with tics and some autism traits. But they also increased cocaine craving in people with cocaine use disorder and showed no meaningful effect for anxiety, PTSD, psychosis or opioid dependence. There were no trials for the treatment of depression.
Key Questions Answered:
A: No. The global data analyzed between 2000 and 2025 demonstrates that removing criminal penalties for personal cannabis possession does not increase population-level consumption. Instead, decriminalization successfully shifts the societal framework from punitive law enforcement to healthcare interventions without driving up usage rates or expanding the consumer base.
A: The key driver is the for-profit corporate structure. In highly commercialized markets, corporate interests are frequently prioritized over public health. This leads to active marketing, increased product availability, and a dramatic escalation in THC potency. This combination has caused an increase in cannabis addiction and a rise in emergency hospital admissions for psychosis and co-occurring psychiatric disorders.
A: Despite growing clinical trends to prescribe medical cannabinoids for mental health, a systematic review of 54 clinical trials found little robust evidence of their effectiveness. Cannabinoids showed no meaningful therapeutic effect for anxiety, PTSD, or opioid dependence, and there were no completed trials evaluating their impact on depression. They did, however, show modest benefits for improving sleep in insomnia, reducing cannabis withdrawal, and helping with certain autism traits.
Editorial Notes:
- This article was edited by a Neuroscience News editor.
- Journal paper reviewed in full.
- Additional context added by our staff.
About this psychosis and cannabis research news
Author: Vittoria D’Alessio
Source: University of Bath
Contact: Vittoria D’Alessio – University of Bath
Image: The image is credited to Neuroscience News
Original Research: Open access.
“International cannabis policies and their association with cannabis use, cannabis use disorder, and other psychiatric” disorders”” by Freeman TP, Lees Thorne R, Wadsworth E, Carney T, Castillo-Carniglia A, Cerdá M, Kalayasiri Q, Kilmer B, Lorenzetti V, Manthey J, Myran DT, Rivera-Aguirre A, Rychert M, Wilson J, Yimer T, Hall W. Lancet Psychiatry
DOI:10.1016/S2215-0366(26)00087-8
Abstract
International cannabis policies and their association with cannabis use, cannabis use disorder, and other psychiatric” disorders”
Cannabis policies vary from strict prohibition to commercialised legalisation and are rapidly evolving worldwide. Here, we reviewed evidence for associations between international cannabis policy changes from 2000–25 and cannabis use, cannabis use disorder, and other psychiatric disorders.
Commercialised legal markets for non-medical use in Canada and the USA were associated with increased prevalence of cannabis use and cannabis use disorder in adults and increases in cannabis potency since legalisation. There was no consistent evidence for associations between policy change and the prevalence or incidence of psychotic disorders.
Commercialised legalisation was associated with an increase in hospital admissions for psychosis, and for psychotic disorders comorbid with cannabis use disorder. Poorly regulated legal access to medical cannabis, in the absence of efficacy and safety data, could increase risk of harm.
Policies that limit commercialisation, such as strictly regulated legalisation of medical or non-medical supply, were not as strongly associated with cannabis use or psychiatric disorders, but long-term evaluation is needed.
There was little evidence that decriminalisation of non-medical cannabis in Europe, Africa, Oceania, and Asia was associated with cannabis use or psychiatric disorders.
