Researchers Have Developed a Russian-Language Method for the Preoperative Mapping of Language Areas

Summary: Researchers have developed a Russian language protocol for neuroimaging that allows for the mapping of individual language areas of the brain before neurosurgery.

Source: HSE

Neurolinguists from HSE University, in collaboration with radiologists from the Pirogov National Medical and Surgical Centre, developed a Russian-language protocol for functional magnetic resonance imaging (fMRI) that makes it possible to map individual language areas before neurosurgical operations.

The study was published in Frontiers in Human Neuroscience.

When neurosurgeons operate on brain tumors, their goal is to remove the pathological tissue while preserving the adjacent areas critical to various motor and cognitive functions, including language, as much as possible.

The ability to preserve the language areas determines whether the patient will have language disorders after the operation and be able to easily communicate with others, hold a job and lead an ordinary life.

The exact location of language areas differs from one person to the next, so special methods must be used to map them in each patient. The most accurate method is direct electrical stimulation during a neurosurgical operation. But sometimes the neurosurgeon needs to know beforehand where a particular patient’s language areas are located to make the best possible plan for the operation. Such preoperative mapping is performed using functional MRI, or fMRI.

While situated in an MRI scanner, the patient performs language-related tasks. Data analysis shows which areas in the brain are activated.

Until now, most protocols for preoperative language mapping by this method were developed in English. Scientists from HSE University have developed the first Russian-language fMRI protocol that uses a language task recommended by the international scientific community—sentence completion.

The patient must read aloud a sentence that is missing the last word (such as “The audience watched a long …”) and then finish the sentence with an appropriate word (such as ‘play’ or ‘movie’). This task is unique in that it involves both language production and comprehension at the sentence level, making it possible to comprehensively map the patient’s language areas.

Researchers validated the protocol in a control group of 18 healthy Russian-speaking volunteers aged 30-53. This proved that the protocol successfully maps the most important language areas in the frontal and temporal lobes of the brain and reveals the individual lateralisation of the language function—that is, the degree to which this function relies on the left and right hemispheres of the brain.

This shows the identified areas of the brain highlighted
Regions of interest used in the analysis. (A–C) Frontal, temporal-parietal and frontal-temporal-parietal region of interest used in the analysis of Dice coefficients and lateralization indices. (D) Eight language-related regions of interest based on the Brainnetome atlas (Fan et al., 2016) implemented in the ICN_atlas toolbox (Kozák et al., 2017), used for assessing individual-level activation. White: pars triangularis of the inferior frontal gyrus; blue: pars opercularis of the inferior frontal gyrus; green: posterior middle frontal gyrus; burgundy: supplementary motor area; red: posterior middle temporal gyrus; cyan: posterior superior temporal gyrus; beige: supramarginal gyrus; yellow: angular gyrus. Credit: The researchers

The researchers also demonstrated the high reliability of the protocol: each volunteer underwent the procedure twice with an interval of several weeks and the results were similar. This is the first Russian-language protocol that has undergone such extensive validation.

Svetlana Malyutina, researcher at the HSE Centre for Language and Brain and a co-author of the article, says that “the first stage of the study has been completed, showing the validity and reliability of the protocol in the control group. We are now doing the most important part—testing the protocol in clinical practice, using it for preoperative speech mapping in patients with brain tumors and epilepsy.

“We plan to analyze whether the protocol works as well in clinical groups as it does in the control group. We will test how well its results match those of intraoperative mapping and, therefore, how widely it should be applied in clinical practice.”

About this brain mapping and language research news

Author: Press Office
Source: HSE
Contact: Press Office – HSE
Image: The image is credited to the researchers

Original Research: Open access.
A New Functional Magnetic Resonance Imaging Localizer for Preoperative Language Mapping Using a Sentence Completion Task: Validity, Choice of Baseline Condition, and Test–Retest Reliability” by Kirill Elin et al. Frontiers in Human Neuroscience


A New Functional Magnetic Resonance Imaging Localizer for Preoperative Language Mapping Using a Sentence Completion Task: Validity, Choice of Baseline Condition, and Test–Retest Reliability

To avoid post-neurosurgical language deficits, intraoperative mapping of the language function in the brain can be complemented with preoperative mapping with functional magnetic resonance imaging (fMRI). The validity of an fMRI “language localizer” paradigm crucially depends on the choice of an optimal language task and baseline condition.

This study presents a new fMRI “language localizer” in Russian using overt sentence completion, a task that comprehensively engages the language function by involving both production and comprehension at the word and sentence level.

The paradigm was validated in 18 neurologically healthy volunteers who participated in two scanning sessions, for estimating test–retest reliability. For the first time, two baseline conditions for the sentence completion task were compared.

At the group level, the paradigm significantly activated both anterior and posterior language-related regions. Individual-level analysis showed that activation was elicited most consistently in the inferior frontal regions, followed by posterior temporal regions and the angular gyrus. Test–retest reliability of activation location, as measured by Dice coefficients, was moderate and thus comparable to previous studies.

Test–retest reliability was higher in the frontal than temporo-parietal region and with the most liberal statistical thresholding compared to two more conservative thresholding methods. Lateralization indices were expectedly left-hemispheric, with greater lateralization in the frontal than temporo-parietal region, and showed moderate test-retest reliability.

Finally, the pseudoword baseline elicited more extensive and more reliable activation, although the syllable baseline appears more feasible for future clinical use. Overall, the study demonstrated the validity and reliability of the sentence completion task for mapping the language function in the brain.

The paradigm needs further validation in a clinical sample of neurosurgical patients. Additionally, the study contributes to general evidence on test–retest reliability of fMRI.

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