Transient Blood Pressure Spikes Coupled to Learning in Brain

Summary: Minor rises in blood pressure due to short-term stressors are linked to a brain area associated with consciousness and motor learning.

Source: University of Gothenburg

Minor everyday rises in blood pressure due to short-term stressors can be linked to a brain area that controls conscious and learned motor skills. This discovery, presented by University of Gothenburg researchers, paves the way for a chance to influence the rises in blood pressure and, in the long run, prevent hypertension.

In roughly half of all people with hypertension — persistently high blood pressure (BP) — there is no known cause. One plausible theory is, however, that hypertension might be the result of a long period of many recurrent BP peaks. Hundreds or thousands of micro-stress events may occur daily — the telephone ringing, a car horn sounding in the street — with BP spiking every time as a result.

For nearly 20 years now, a University of Gothenburg research group has been investigating how this kind of micro-stress affects nerve signals to our muscles and the throughput (perfusion) of blood in their vessels (muscle vasculature). In half of the over 150 men included in the group’s studies to date, the pattern of their reaction system leads to BP peaks, while for the other half the reactions taking place in their bodies do not bring about any change in BP.

Ultramodern brain-imaging techniques

The latest results are published in Scientific Reports. For the study, 20 men aged 19–45 were examined. The experiment involved triggering a response in the nervous system with unexpected electric shocks that emulate the sudden and/or stressful stimuli to which we are exposed daily. The researchers combined two measurement methods.

In one, a traditional research technique called microneurography, very thin needle electrodes are used to probe the signaling in nerve fibers (specifically, muscle sympathetic nerve activity, MSNA) directed to the vascular bed (blood vessels) of the muscles. The other was a modern brain-imaging technique known as magnetoencephalography (MEG).

For the first time, the researchers can now link the increased susceptibility to micro-stress to a reflex-like signal in the brain. The brain area (the “rolandic area”) that activates the signal controls several conscious brain functions. This finding opens the question of whether the BP peaks may be learned and could therefore also, with training, be eliminated.

“We see a surprisingly strong connection between the peripheral autonomic vascular reaction, which takes place subconsciously, and a reaction pattern — one that was already previously well known — in a part of the brain where emotional impressions and motor skills undergo conscious interpretation.

“This raises questions about how independently the ‘autonomic nervous system’, as it’s called, really works,” says Mikael Elam, Professor of Clinical Neurophysiology at Sahlgrenska Academy, University of Gothenburg.

Long road ahead to clinical use

The idea that the discovery might come to be used to prevent hypertension is not unrealistic, but much research remains to be done.

“If we can develop ways of boosting the signal-to-noise ratio, in the future it may be possible to extract the relevant brain signals from a regular electroencephalogram [EEG], which is available in every Swedish hospital today. That would enable us, at an early stage, to identify people who react with BP spikes before they develop hypertension. Many other opportunities for preventive measures and research would then follow,” says Justin Schneiderman, Senior Lecturer in experimental multimodal neuroimaging at Sahlgrenska Academy, University of Gothenburg.

Environmental factors decisive

Interestingly, our environment seems to matter more than our genetic code when it comes to which reaction pattern we develop, and thus whether we experience many daily BP spikes or not. An earlier study by the research group on identical twins showed that basic activity in the twins’ blood-vessel-regulating autonomic nervous systems was very similar, while their stress-triggered reactions diverged.

This shows a drawing of a heart and brain
For the first time, the researchers can now link the increased susceptibility to micro-stress to a reflex-like signal in the brain. Image is in the public domain

“One may speculate that, today, many people have learned to suppress the primitive fight-or-flight response, since it’s not that relevant in modern society. It’s an impulse that prepares us for action, by reducing the vasoconstrictor nerve activity and thereby increase blood flow in the muscles. In terms of long-term health consequences, it might be beneficial to preserve the old flight-or-fight impulse in response to sudden stressors,” Elam ponders.

A wide-ranging collaboration

The research group hopes to be able to facilitate studies at the population level, monitoring large groups of people over a long period. This would enable investigation of, first, whether individuals with reaction patterns that cause many peaks in blood pressure during the day are indeed at increased risk of developing hypertension later in life and, second, whether influencing this reaction pattern is feasible.

The research that maps the biological processes and signals controlling autonomic regulation of our blood vessels is taking place in a wide-ranging collaboration involving the University of Gothenburg, Sahlgrenska University Hospital, and Chalmers University of Technology.

About this learning and hypertension research news

Author: Mikael Elam
Source: University of Gothenburg
Contact: Mikael Elam – University of Gothenburg
Image: The image is in the public domain

Original Research: Open access.
Brain structural and functional correlates to defense-related inhibition of muscle sympathetic nerve activity in man” by Mikael Elam et al. Scientific Reports


Brain structural and functional correlates to defense-related inhibition of muscle sympathetic nerve activity in man

An individual’s blood pressure (BP) reactivity to stress is linked to increased risk of hypertension and cardiovascular disease. However, inter- and intra-individual BP variability makes understanding the coupling between stress, BP reactivity, and long-term outcomes challenging.

Previous microneurographic studies of sympathetic signaling to muscle vasculature (i.e. muscle sympathetic nerve activity, MSNA) have established a neural predictor for an individual’s BP reactivity during short-lasting stress. Unfortunately, this method is invasive, technically demanding, and time-consuming and thus not optimal for widespread use. Potential central nervous system correlates have not been investigated.

We used MagnetoEncephaloGraphy and Magnetic Resonance Imaging to search for neural correlates to sympathetic response profiles within the central autonomic network and sensorimotor (Rolandic) regions in 20 healthy young males.

The main correlates include (a) Rolandic beta rebound and an anterior cingulate cortex (ACC) response elicited by sudden stimulation and (b) cortical thickness in the ACC. Our findings highlight the involvement of the ACC in reactions to stress entailing peripheral sympathetic responses to environmental stimuli. The Rolandic response furthermore indicates a surprisingly strong link between somatosensory and autonomic processes.

Our results thus demonstrate the potential in using non-invasive neuroimaging-based measures of stress-related MSNA reactions, previously assessed only using invasive microneurography.

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