This shows a woman's head.
The researchers hope someday that those signals might be directed to implanted wireless communication chips in the peripheral nerve to allow amputees to control prosthetic limbs. Credit: Neuroscience News

Researchers Invent E-skin That ‘Talks’ to the Brain

Summary: Researchers have developed an artificial electronic skin (e-skin) capable of converting sensory inputs into electrical signals that the brain can interpret. This skin-like material incorporates soft integrated circuits and boasts a variety of sensory abilities, including temperature and pressure detection.

This advance could facilitate the creation of prosthetic limbs with sensory feedback or advanced medical devices. The e-skin operates at a low voltage and can endure continuous stretching without losing its electrical properties.

Key Facts:

  1. This is the first soft integrated circuit capable of converting sensory information into brain-readable electrical signals.
  2. The e-skin can operate on just 5 volts, detecting stimuli akin to natural skin.
  3. The new e-skin is composed of skin-like materials layered with networks of organic nanostructures, allowing it to sense various inputs like pressure, temperature, strain, and chemicals while maintaining its electrical properties even when stretched.

Source: Stanford

Mechanoreceptors in human skin can sense the delicate weight of a butterfly, feel the heat of a nearby flame or a cool drink, understand whether a hand is raised in a fist or a peace sign, and count the pulse of a loved one with a gentle touch.

Engineers eager to create artificial electronic skin have so far been able to fashion soft, flexible materials that mimic each of these remarkable senses, but never have they created a single sheet with skin-like materials that can directly talk to the brain – until now.

While previous efforts required rigid electronics to convert the sensed signal into electrical pulses that the brain can read, researchers at Stanford University have produced soft integrated circuits that convert sensed pressure or temperature to electrical signals similar to the nerve impulses to communicate with the brain.

The researchers hope someday that those signals might be directed to implanted wireless communication chips in the peripheral nerve to allow amputees to control prosthetic limbs. Other potential uses might include new-age implantable or wearable medical devices.

“We’ve been working on a monolithic e-skin for some time. The hurdle was not so much finding mechanisms to mimic the remarkable sensory abilities of human touch, but bringing them together using only skin-like materials,” said Zhenan Bao, K.K. Lee Professor in Chemical Engineering and senior author of the study appearing in the journal Science.

“Much of that challenge came down to advancing the skin-like electronic materials so that they can be incorporated into integrated circuits with sufficient complexity to generate nerve-like pulse trains and low enough operating voltage to be used safely on the human body,” said Weichen Wang, a doctoral candidate in Bao’s lab, who is a first author of the paper. Wang has been working on this prototype for 3 years.

Layers of technology

The goal was a soft integrated circuit that could mimic the mechanism of sensory receptors and run efficiently at a low voltage. Unfortunately, Wang’s first attempts demanded upwards of 30 or more volts and could not realize enough circuit functionality. “This new e-skin runs on just 5 volts and can detect stimuli similar to real skin,” he said.

The e-skin is soft and stretchable, while also being able to mimic sense of touch and run efficiently at a low voltage. (Image credit: Jiancheng Lai and Weichen Wang of Bao Research Group at Stanford University)

Artificial skin will be critical to new-age prosthetic limbs that not only restore movement and functions, like grasping, but also provide sensory feedback (proprioception) that helps the user control the device with precision.

Not only that but the sensory-skin material itself must stretch and return without fail, time and time again, all while never losing its nerve-like electrical characteristics.

The team invented a tri-layer dielectric structure that helped increase the mobility of electrical charge carriers by 30 times compared to a single-layer dielectrics, allowing the circuits to operate at low voltage.

Interestingly, one of the layers in the tri-layer is nitrile, the same rubber that is used in surgical gloves. The majority of e-skin is made of many layers of skin-like materials.

Integrated in each layer are networks of organic nanostructures that transmit electrical signals even when stretched. These networks can be engineered to sense pressure, temperature, strain, and chemicals.

Each sensory input has its own integrated circuit. Then all the various sensory layers must be sandwiched together into a single monolithic material that does not delaminate, tear, or lose electrical function.

Each electronic layer is just a few tens to hundred nanometers thick and the finished material of half a dozen or so layers is less than a micron.

“But that’s actually too thin to be handled easily, so we use a substrate to support it, which brings our e-skin to about 25-50 microns thick – about the thickness of a sheet of paper,” Bao said. “It is in a similar thickness range of the outer layer of human skin.”

Next-generation advances

The system is the first to combine sensing and all the desired electrical and mechanical features of human skin in a soft, durable form that could be used in next-generation prosthetic skins and innovative human-machine interfaces to provide a human-like sense of touch.

Their prototype complete, Bao, Wang, and team now embark on increasing complexity and scalability of their technology, adding wireless functionality, and ways to interface with the brain and the peripheral of the body.

Funding: This research was funded by the Stanford Wearable Electronics Initiative (eWEAR), Stanford SystemX Alliance, and the Wu Tsai Neuroscience Institute. Part of this work was performed at the Stanford Nano Shared Facilities (SNSF), which is supported by the National Science Foundation.

About this neurotech research news

Author: Jill Wu
Source: Stanford
Contact: Jill Wu – Stanford
Image: The header image is credited to Neuroscience News. The image of the e-skin is credited to Jiancheng Lai and Weichen Wang of Bao Research Group at Stanford University

Original Research: Closed access.
Neuromorphic sensorimotor loop embodied by monolithically integrated, low-voltage, soft e-skin” by Zhenan Bao et al. Science


Neuromorphic sensorimotor loop embodied by monolithically integrated, low-voltage, soft e-skin

Artificial skin that simultaneously mimics sensory feedback and mechanical properties of natural skin holds substantial promise for next-generation robotic and medical devices. However, achieving such a biomimetic system that can seamlessly integrate with the human body remains a challenge.

Through rational design and engineering of material properties, device structures, and system architectures, we realized a monolithic soft prosthetic electronic skin (e-skin). It is capable of multimodal perception, neuromorphic pulse-train signal generation, and closed-loop actuation.

With a trilayer, high-permittivity elastomeric dielectric, we achieved a low subthreshold swing comparable to that of polycrystalline silicon transistors, a low operation voltage, low power consumption, and medium-scale circuit integration complexity for stretchable organic devices.

Our e-skin mimics the biological sensorimotor loop, whereby a solid-state synaptic transistor elicits stronger actuation when a stimulus of increasing pressure is applied.

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