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The research team found that the D-dimer blood test was useful to identify those patients at highest risk of venous thromboembolism when admitted to hospital. Image is in the public domain.

High rate of blood clots in COVID-19

Summary: Coronavirus has been linked to a higher rate of developing venous thromboembolism. A D-dimer blood test is a useful way to identify COVID-19 patients at a higher risk of venous thromboembolism.

Source: University of Sussex

COVID-19 is associated with a high incidence of venous thromboembolism, blood clots in the venous circulation, according to a study conducted by researchers at Brighton and Sussex Medical School (BSMS), UK. In a series of 274 consecutive cases of COVID-19 admitted to hospital, a significant percentage (7.7%) were diagnosed with venous thromboembolism. The most common type of venous thromboembolism, seen in 76.2% of these cases, was pulmonary embolism, a blood clot on the lungs. The research team found that the D-dimer blood test was useful to identify those patients at highest risk of venous thromboembolism when admitted to hospital.

Lead author, Dr. Chi Eziefula, Senior Lecturer in Infection at BSMS, said: “Identifying which patients have a risk of, and clinical evidence of, a venous thromboembolism in COVID-19 is highly important for two reasons. Firstly, because venous thromboembolism is linked to a risk of death and secondly because it is treatable with anticoagulant medications.”

Dr. Tim Chevassut, Reader in Haematology at BSMS, said: “This study signals the importance of further research to explore the pathological mechanisms specific to COVID-19. It also highlights the urgent need for clinical trials to evaluate the role of anticoagulation treatment for the prevention of deaths and morbidity from COVID-19 infection.”

About this coronavirus research article

Source:
University of Sussex
Media Contacts:
Press Office – University of Sussex
Image Source:
The image is in the public domain.

Original Research: Open access
“Thrombotic risk in COVID-19: a case series and case–control study”. by Simon M Stoneham et al.
Clinical Medicine doi:10.7861/clinmed.2020-0228

Abstract

Thrombotic risk in COVID-19: a case series and case–control study

We designed a head-mounted three-photon microscope for imaging deep cortical layer neuronal activity in a freely moving rat. Delivery of high-energy excitation pulses at 1,320 nm required both a hollow-core fiber whose transmission properties did not change with fiber movement and dispersion compensation. These developments enabled imaging at >1.1 mm below the cortical surface and stable imaging of layer 5 neuronal activity for >1 h in freely moving rats performing a range of behaviors.

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