Dynamic stimulation of the visual cortex allows blind and sighted people to ‘see’ shapes

Summary: A visual cortical prosthesis can restore sight by bypassing damage to the eyes and delivering visual information retrieved from a camera directly to the brain.

Source: Cell Press

For most adults who lose their vision, blindness results from damage to the eyes or optic nerve while the brain remains intact. For decades, researchers have proposed developing a device that could restore sight by bypassing damaged eyes and delivering visual information from a camera directly to the brain. In a paper publishing in the journal Cell on May 14, a team of investigators at Baylor College of Medicine in Houston report that they are one step closer to this goal. They describe an approach in which implanted electrodes are stimulated in a dynamic sequence, essentially “tracing” shapes on the surface of the visual cortex that participants were able to “see.”

“When we used electrical stimulation to dynamically trace letters directly on patients’ brains, they were able to ‘see’ the intended letter shapes and could correctly identify different letters,” senior author Daniel Yoshor says. “They described seeing glowing spots or lines forming the letters, like skywriting.”

Previous attempts to stimulate the visual cortex have been less successful. Earlier methods treated each electrode like a pixel in a visual display, stimulating many of them at the same time. Participants could detect spots of light but found it hard to discern visual objects or forms. “Rather than trying to build shapes from multiple spots of light, we traced outlines,” says first author Michael Beauchamp. “Our inspiration for this was the idea of tracing a letter in the palm of someone’s hand.”

This is a diagram from the study
This figure illustrates how dynamic stimulation to the visual cortex enables participants to ‘see’ shapes. Image is credited to Beauchamp et al./Cell.

The investigators tested the approach in four sighted people who had electrodes implanted in their brains to monitor epilepsy and two blind people who had electrodes implanted over their visual cortex as part of a study of a visual cortical prosthetic device. Stimulation of multiple electrodes in sequences produced perceptions of shapes that subjects were able to correctly identify as specific letters.

The approach, the researchers say, demonstrates that it could be possible for blind people to regain the ability to detect and recognize visual forms by using technology that inputs visual information directly into the brain, should they wish to. The researchers note, however, that several obstacles must be overcome before this technology could be implemented in clinical practice.

“The primary visual cortex, where the electrodes were implanted, contains half a billion neurons. In this study we stimulated only a small fraction of these neurons with a handful of electrodes,” Beauchamp says. “An important next step will be to work with neuroengineers to develop electrode arrays with thousands of electrodes, allowing us to stimulate more precisely. Together with new hardware, improved stimulation algorithms will help realize the dream of delivering useful visual information to blind people.”

Funding: This work was supported by the National Institutes of Health.

About this neuroscience research article

Source:
Cell Press
Media Contacts:
Carly Britton – Cell Press
Image Source:
The image is credited to Beauchamp et al./Cell.

Original Research: Open access (PDF)
” Dynamic Stimulation of Visual Cortex Produces Form Vision in Sighted and Blind Humans”. by Daniel Yoshor et al.
Current Biology doi:10.1016/j.cell.2020.04.033

Abstract

Dynamic Stimulation of Visual Cortex Produces Form Vision in Sighted and Blind Humans

Highlights
• Visual cortical prosthetic stimulation paradigms were examined
• Letters or other shapes were traced on the surface of cortex with electrical current
• Static stimulation was unable to produce letter percepts in participants
• Dynamic current steering evoked percepts of letter forms by blind and sighted participants

Summary
A visual cortical prosthesis (VCP) has long been proposed as a strategy for restoring useful vision to the blind, under the assumption that visual percepts of small spots of light produced with electrical stimulation of visual cortex (phosphenes) will combine into coherent percepts of visual forms, like pixels on a video screen. We tested an alternative strategy in which shapes were traced on the surface of visual cortex by stimulating electrodes in dynamic sequence. In both sighted and blind participants, dynamic stimulation enabled accurate recognition of letter shapes predicted by the brain’s spatial map of the visual world. Forms were presented and recognized rapidly by blind participants, up to 86 forms per minute. These findings demonstrate that a brain prosthetic can produce coherent percepts of visual forms.

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