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When Language Suddenly Fails

Summary: Researchers at Max Planck Institute investigate why certain language abilities are lost as a result of a traumatic brain injury, and how others can be regained.

Source: Max Planck Institute

Why certain linguistic abilities can be regained after a stroke while others are lost forever.

Talking to each other is a complex matter. While chatting we have to recognise single words and phrases out of a flood of sounds. In parallel we have to think about an answer and to plan the movements of our lips and tongue. Every single step, from analysing the words to producing the language, requires a range of brain areas to work together. Until now, it remained a mystery as to how they collaborate — and what happens if one of the central areas is damaged.

Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) in Leipzig discovered what happens when two crucial brain regions of our linguistic comprehension are inactive: They observed that failure of some regions can be compensated by the commitment of other areas, whereas others cannot.

“If the region in which the meaning of language is processed is impaired, the so-called left angular gyrus, our brain is able to balance it well. In this case the neighbouring area, the anterior inferior frontal gyrus, stands in and enhances its activity. This is surprising since it is originally responsible for the rhythmic structure of the words”, study leader Gesa Hartwigsen explains. By taking on this role, the meaning of the words can be recognised nearly as fast as when the appropriate area fulfils its task. “If the anterior inferior frontal gyrus itself is impaired, its failure can hardly be compensated and its tasks are not taken over by another part of the language network, making it much harder to analyse the rhythmic structure of a word, that is to say its syllables.”

The scientists presume that the ability to compensate an impaired process by another part of the brain depends on the hierarchy level on which the language is perturbed: Processing the rhythm of a word is such a basic mechanism that cannot be simply overtaken by another part. More complex processing stages, such as analysing the meaning of a word, could on the contrary be supported by simpler processes, since they are one of the underlying steps. More general processes can then provide support in order to maintain this ability.

Hartwigsen and her team conclude two things from these findings: “We can now estimate which injuries could be counterbalanced and on which of these it is worth focusing language training, for instance on the network which fills in”, says the leader of the research group modulation of language networks. Furthermore, they confirmed the hypothesis of a hierarchical structure of language. According to this, during the processing of language, complex steps build on basic steps. Before we analyse the meaning of the word we have to process its sounds.

Image shows a person with a TMS machine.

The scientists presume that the ability to compensate an impaired process by another part of the brain depends on the hierarchy level on which the language is perturbed: Processing the rhythm of a word is such a basic mechanism that cannot be simply overtaken by another part. They gained their insights by using the Transcranial Magnetic Stimulation. NeuroscienceNews.com image is credited to MPI CBS.

The neuroscientists examined these relationships with the help of transcranial magnetic stimulation (TMS). This method can interrupt the activity of single brain regions for a short period of time and can therefore measure the brain’s reaction to this impairment. TMS therefore uses magnetic fields to specifically inhibit or stimulate single brain areas by weak electric stimulation through the scalp.

In this study of 17 healthy participants, the team inhibited both the areas of word meaning and of rhythmic structure for a short period. Subsequently they compared the abilities of these people in linguistic tasks – and noticed a considerably weaker performance only in those which demanded word analysing.

About this neuroscience research article

Source: Gesa Hartwigsen – Max Planck Institute
Image Source: NeuroscienceNews.com image is credited to MPI CBS.
Original Reserch: Full open access research for “Rapid short-term reorganization in the language network” by Gesa Hartwigsen, Danilo Bzdok, Maren Klein, Max Wawrzyniak, Anika Stockert, Katrin Wrede, Joseph Classen, and Dorothee Saur in eLife. Published online May 24 doi:10.7554/eLife.25964

Cite This NeuroscienceNews.com Article
Max Planck Institute “Purpose in Life by Day Linked to Better Sleep at Night.” NeuroscienceNews. NeuroscienceNews, 12 July 2017.
<http://neurosciencenews.com/tms-language-7068/>.
Max Planck Institute (2017, July 12). Purpose in Life by Day Linked to Better Sleep at Night. NeuroscienceNew. Retrieved July 12, 2017 from http://neurosciencenews.com/tms-language-7068/
Max Planck Institute “Purpose in Life by Day Linked to Better Sleep at Night.” http://neurosciencenews.com/tms-language-7068/ (accessed July 12, 2017).

Abstract

Rapid short-term reorganization in the language network

The adaptive potential of the language network to compensate for lesions remains elusive. We show that perturbation of a semantic region in the healthy brain induced suppression of activity in a large semantic network and upregulation of neighbouring phonological areas. After perturbation, the disrupted area increased its inhibitory influence on another semantic key node. The inhibitory influence predicted the individual delay in response speed, indicating that inhibition at remote nodes is functionally relevant. Individual disruption predicted the upregulation of semantic activity in phonological regions. In contrast, perturbation over a phonological region suppressed activity in the network and disrupted behaviour without inducing upregulation. The beneficial contribution of a neighbouring network might thus depend on the level of functional disruption and may be interpreted to reflect a differential compensatory potential of distinct language networks. These results might reveal generic mechanisms of plasticity in cognitive networks and inform models of language reorganization.

“Rapid short-term reorganization in the language network” by Gesa Hartwigsen, Danilo Bzdok, Maren Klein, Max Wawrzyniak, Anika Stockert, Katrin Wrede, Joseph Classen, and Dorothee Saur in eLife. Published online May 24 doi:10.7554/eLife.25964

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