Summary: Researchers have modified transcranial magnetic stimulation (TMS), significantly improving its effectiveness in treating hard-to-treat depression. In a recent study, this novel TMS protocol achieved a 66% response rate and 42% acute remission in patients with major depressive disorder, surpassing the standard FDA-approved protocol’s 29% response rate.
The new approach combines traditional left-brain stimulation with high-frequency bursts to the right brain, showing effectiveness in younger adults and those with conditions like anxiety and PTSD. This breakthrough offers hope for more effective, side-effect-free treatments for mental illnesses.
Key Facts:
- The enhanced TMS protocol demonstrated a 66% response rate and 42% remission in major depressive disorder, significantly higher than standard treatments.
- This new method includes additional right-brain stimulation, previously shown to aid in reducing anxiety and PTSD symptoms.
- The study’s success, especially in a younger demographic, suggests potential for broader, more effective treatment options for mental health disorders.
Source: Family Care Center
By making slight modifications to an already approved brain stimulation technique called transcranial magnetic stimulation (TMS), researchers have reported profound improvement in patients with hard-to-treat depression. Overall, 66% of patients with major depressive disorder who took part in the study responded to the novel treatment, and 42% showed acute remission.
This is significantly higher than the 29% response rate reported for the standard FDA-approved protocol and also better than the response rates reported for alternative evidence-based protocols.
“The findings are significant, particularly for patients who have tried other treatments and not seen desired results,” said Sabrina Segal, Ph.D., Director of Research at Family Care Center, who led the study, which was recently published in Brain Stimulation Journal, a publication focused on the field of brain stimulation techniques and research.
She added, “Our TMS protocol reduced patient symptoms considerably more than other approaches and with virtually no side effects.”
Only 30-50% of patients experience full recovery or remission when treated with psychotherapy or medication. Even when medications do work, they can sometimes cause side effects ranging from weight gain to sexual dysfunction, and in some cases, can actually make depression symptoms worse.
Patients who try several types of therapy unsuccessfully are often considered treatment-resistant, especially those who suffer from major depressive disorder, a problem so pervasive that it’s considered the leading cause of disability worldwide, according to the World Health Organization.
“This is a global epidemic,” said Dr. Segal. “Simply put, we need more effective treatment options, and that’s where TMS can make an impact.”
During the trial, more than three dozen patients underwent TMS to a region in the front left portion of the brain. It’s a technique that’s already approved by the FDA for the treatment of major depressive disorder; however, it has only been shown to offer a meaningful reduction in depression symptoms in about 29% of patients.
“We took that approach a step further,” said Charles L. Weber, DO, FASAM, Chief Medical Officer and Founder of Family Care Center. “What we did was follow up the more traditional stimulation of 15 minutes to the left side of the brain, with three minutes of high frequency, short bursts of stimulation to an area in the right side of the brain.”
He added, “This type of stimulation to the right side has been associated with improvements in symptoms related to anxiety and post-traumatic stress disorder (PTSD). A couple of recent studies have demonstrated a reduction in depressive symptoms in older adults; however, this is the first study to show the effectiveness of the right-side stimulation on reduction of depressive symptoms in younger adults.”
The fact that two out of three patients showed a response to this approach and nearly half had acute remission is made more encouraging by the fact that most patients in this study suffered from other conditions as well, such as anxiety and PTSD.
“There is much more research needed in those areas, but given our initial success, we’re optimistic about the potential, particularly given their demographics,” said Dr. Segal.”
The study consisted of patients whose mean age was 42.5 years, more than 20 years younger than recent similar studies that used TMS to evaluate the impact on patients with so-called late-life depression.
Developing new therapies for younger patients could help them find effective treatments much earlier in life, significantly reduce lost productivity and the cost of failed therapies, and could potentially become an option for younger veterans, in particular, millions of whom struggle to find effective therapies to treat PTSD.
Before the study began, each patient charted their symptoms using a standard scale, with zero being no symptoms and 27 representing the most severe. At the outset, patients had a mean score of 18.18. During the course of the trial, symptoms improved to a mean score of 10.29, and by the end of the study, they had been cut by more than half at just over 8, with many achieving acute remission.
“We are making huge strides in understanding how TMS works, but we’re still just scratching the surface,” said Dr. Segal. “Hopefully, this could someday become a first-line therapy for millions who suffer from a variety of mental illnesses and spare them the devastating toll they often take on their lives.”
About this depression and neurotech research news
Author: Chelsea Taylor
Source: Family Care Center
Contact: Chelsea Taylor – Family Care Center
Image: The image is credited to Neuroscience News
Original Research: Open access.
“A novel sequential bilateral neurostimulation approach for treatment-resistant depression involving high-frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex and intermittent theta burst to the right dorsolateral prefrontal cortex” by Sabrina Segal et al. Brain Stimulation
Abstract
A novel sequential bilateral neurostimulation approach for treatment-resistant depression involving high-frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex and intermittent theta burst to the right dorsolateral prefrontal cortex
High-frequency unilateral repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex (LDLPFC) is an established approach for treatment-resistant major depressive disorder (TR-MDD).
However, typical response rates defined as >50 % reduction in depression scale scores have been inadequate; a recent systematic review and meta-analysis estimated response rates at approximately 29 %.
Suboptimal response and remission rates have led to the development of novel protocols to serve as augmentation or alternative treatment strategies. These include low-frequency (≤1 Hz) unilateral stimulation to the right dorsolateral prefrontal cortex (RDLPFC), unilateral and bilateral theta burst stimulation to the LDLPFC and RDLPFC, and sequential bilateral (SBL) stimulation.
Multiple meta-analyses of randomized controlled trials (RCTs) have compared SBL protocols to unilateral protocols and found that SBL TMS is more effective than sham conditions but less effective than high-frequency left unilateral (HF-LUL) or low-frequency right unilateral (LF-RUL) TMS; non-responder rates continue to exceed 40 %. However, the SBL protocols applied low-frequency (e.g., 1 Hz or continuous TBS (cTBS), rather than high-frequency (e.g., 10 Hz or intermittent TBS; iTBS) stimulation to the RDLPFC.
