Suicide attempt survivors have lower sensitivity to bodily signals

The interoceptive numbing was linked to lower brain activity in the insular cortex.

Summary: Suicide survivors have higher pain tolerance and are less sensitive to bodily signals associated with their breathing and heart. Researchers found those who attempted suicide were able to tolerate the breath-hold and cold-pressor interoceptive challenges significantly longer than those who had no history of suicidal behavior. The interoceptive numbing was linked to lower brain activity in the insular cortex.

Source: eLife

People who have survived a suicide attempt are less sensitive to bodily signals related to their heart and breath, and have a higher tolerance for pain, suggest new findings published today in eLife.

Accurately predicting the risk of suicide in an individual is one of the greatest challenges encountered by clinicians. By identifying physical characteristics that differentiate people who have attempted suicide from those who have not, the study paves the way for future research aimed at identifying biological indicators of suicide risk.

Our brain constantly monitors the status of bodily signals that we need to stay alive, such as our heartbeat, our breath and pain caused by tissue damage to our skin. ‘Interoception’ describes the way the nervous system tracks the internal state of the body, helping us to perceive potential or actual threats and to act accordingly.

“Unlike most organisms, some humans are able to counteract these survival instincts through the act of suicide,” explains lead author Danielle DeVille, a PhD student at the Laureate Institute for Brain Research, Tulsa, Oklahoma, US. “While experts have strived for decades to understand and prevent these deaths, we still don’t know enough about the factors that contribute to suicidal behaviour.”

To address this gap, DeVille and her colleagues conducted the first study that looks at whether blunted interoception is associated with a history of suicide attempts in people with psychiatric disorders, including depression, anxiety and post-traumatic stress disorder. Their study involved 34 participants with a history of suicide attempts in the last five years as compared to a matched psychiatric reference sample of 68 participants with no history of suicide attempts.

The team examined interoceptive processing in the participants using a panel of tasks. These include a breath-hold challenge, a cold-pressor test – where an individual immerses a hand in icy water and has their heart rate and skin conductance measured – and heartbeat perception. The researchers found that those who had attempted suicide tolerated the breath-hold and cold-pressor challenges for significantly longer than those who had not. Additionally, this group was less able to accurately perceive their heartbeat than non-attempters.

This shows a woman's legs
Accurately predicting the risk of suicide in an individual is one of the greatest challenges encountered by clinicians The image is in the public domain.

“We found that this ‘interoceptive numbing’ was linked to lower brain activity in the insular cortex, a region that closely tracks the internal state of the body,” explains senior author Sahib Khalsa, Director of Clinical Operations at the Laureate Institute for Brain Research. “This numbing was not influenced by the presence a psychiatric disorder, by a history of having considered suicide, or by having taken psychiatric medications, and this suggests it was most closely linked to the act of attempting suicide.”

Khalsa adds that these findings come with a number of limitations, including the fact that the study did not fully examine whether a history of considering suicide, versus making an actual attempt, has an independent impact on interoception. “It is also difficult to judge from our study whether the observed differences in interoception represent innate characteristics of the individuals involved, or whether they reflect an emerging response as they progressed from suicidal thinking to suicidal action,” he says.

Despite these limitations, the authors say their work reveals a possible role of interoceptive dysfunction in distinguishing individuals at risk of suicide. It also lays the groundwork for further studies to determine whether measuring interoception in individuals can improve the ability to predict their suicide risk.

About this neuroscience research article

Source:
eLife
Media Contacts:
Emily Packer – eLife
Image Source:
The image is in the public domain.

Original Research: Open access
“Diminished responses to bodily threat and blunted interoception in suicide attempters”. Danielle C DeVille, Rayus Kuplicki, Jennifer L Stewart, Tulsa 1000 Investigators, Martin P Paulus, Sahib S Khalsa.
eLife doi:10.7554/eLife.51593.

Abstract

Diminished responses to bodily threat and blunted interoception in suicide attempters

Psychological theories of suicide suggest that certain traits may reduce aversion to physical threat and increase the probability of transitioning from suicidal ideation to action. Here, we investigated whether blunted sensitivity to bodily signals is associated with suicidal action by comparing individuals with a history of attempted suicide to a matched psychiatric reference sample without suicide attempts. We examined interoceptive processing across a panel of tasks: breath-hold challenge, cold-pressor challenge, and heartbeat perception during and outside of functional magnetic resonance imaging. Suicide attempters tolerated the breath-hold and cold-pressor challenges for significantly longer and displayed lower heartbeat perception accuracy than non-attempters. These differences were mirrored by reduced activation of the mid/posterior insula during attention to heartbeat sensations. Our findings suggest that suicide attempters exhibit an ‘interoceptive numbing’ characterized by increased tolerance for aversive sensations and decreased awareness of non-aversive sensations. We conclude that blunted interoception may be implicated in suicidal behavior.

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