A Variety of Factors Beyond Age Influence Reaction Time

Summary: A new study reveals a number of different factors, including smoking, age, education levels, sex, handedness, and family medical history, which can have an impact on reaction time.

Source: TGen

Reaction time, as a measure of brain health, is influenced by aging and a variety of other factors, including education, sex, smoking, dizziness, the number of daily medications, family medical history, and even whether one favors using their right or left hand.

In a study published in Nature Aging and Mechanisms of Disease, researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, looked at data collected from more than 159,000 participants in TGen’s online cognitive test called MindCrowd (and augmented with data from an additional 500,000 individuals from a biomedical research resource in the United Kingdom known as the UK Biobank) to illustrate how reaction time can be used to measure brain health.

“Our findings have begun to pull back the curtain on the intricate network connecting processing speed and cognition to more accurately describe the comparisons of healthy, versus pathological, brain aging,” said Matt Huentelman, Ph.D., TGen Professor of Neurogenomics, a MindCrowd founder, and the study’s senior author.

Reaction time is a product of processing speed, or efficiency, in the central nervous system and is an essential factor in higher cognitive functions. Age is the main factor known to influence reaction time, with processing speed a limiting factor for most aspects of cognition during aging, especially memory.

The findings collectively suggest that reaction time performance is a valuable index of age-related cognitive decline, healthy brain aging, and neurodevelopment.

The key variable observed in 75,666 MindCrowd participants was simple visual reaction time (svRT) as measured in milliseconds: participants logged a keystroke whenever a pink sphere appeared at random intervals on the computer screen. The researchers also assessed participants through a word pair memory test. The results showed that both processing speed and memory declined from younger to older ages.

Sample size and diversity matter

In contrast to earlier studies, this work includes over 200,000 participants representing a wide range of factors associated with cognitive performance and Alzheimer’s disease risk.

“We need a deeper understanding of the normal variation of reaction time and the genetic and environmental factors associated with reaction time performance,” said Joshua Talboom, Ph.D., a postdoctoral fellow in Dr. Huentelman’s lab and the lead author of the study.

“We used both the MindCrowd and UK Biobank data, comprising over 233,000 combined participants, to model reaction time as a function of demographic, health, medical and lifestyle factors.”

MindCrowd data showed that average reaction time slowed by 7 milliseconds per year. Besides age, factors that also slowed reaction time included smoking, dizziness, the number of daily medications, and a family history of Alzheimer’s disease.

Other findings include: men, on average, being 34 milliseconds faster than women; the more education one attained, the faster the reaction time; and those age 20-40 with a left-hand preference posted a higher reaction time than their right-handed counterparts, though individuals 40-60 years old showed no difference whichever hand they preferred.

Although the differences were measured in milliseconds, they were validated by the sheer number of participants. In addition, data from the UK Biobank further validated the findings among those in the MindCrowd study.

“This study’s large participant numbers, as well as broad age and surveyed data range, lends it to be a substantial evaluation of reaction time across the aging spectrum,” said Dr. Talboom, who suggests that the findings are important because they will help develop a valid model of healthy brain aging.

Potential savings could reach billions of dollars

“Many things in our study linked to brain health during aging, like biological sex, are not our choice. However, not smoking is an example of a choice we can make to have a healthier brain during aging. Mitigating age- or disease-related cognitive decline, allowing maintenance of independence by even a few years, would have many benefits,” said Dr. Huentelman, “including saving billions of dollars in healthcare costs and lost productivity of caregivers, while improving the quality of life for the aging population. Part of our overall goal is to enable the cognitive healthspan to better match the human lifespan.”

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Reaction time is a product of processing speed, or efficiency, in the central nervous system and is an essential factor in higher cognitive functions. Image is in the public domain

He added, “With MindCrowd recruitment ever-increasing, we aim to continue to refine the knowledge necessary to optimize cognitive performance throughout life.”

Contributing to this study were: City of Hope National Medical Center, Arizona Alzheimer’s Consortium, Norwegian University of Science and Technology, University of Miami Miller School of Medicine and its Evelyn F. McKnight Brain Institute, and the University of Arizona.

Funding: The study — Modifiers of Age-Associated Variation in Reaction Time: Two Separate, Large Cohorts Reveal Potential Modifiers of Age-Associated Variation in Visual Reaction Time Performance — was supported by: the UK Biobank, Mike Mueller and the Mueller Family Charitable Trust, the Arizona Department of Health Services through the Arizona Alzheimer’s Consortium, Flinn Foundation, The McKnight Brain Research Foundation, the National Institute on Aging, many anonymous donors, and institutional support from TGen, City of Hope, and the University of Arizona.

About this neuroscience research news

Source: TGen
Contact: Steve Yozwiak – TGen
Image: The image is in the public domain

Original Research: Open access.
Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance” by J. S. Talboom, M. D. De Both, M. A. Naymik, A. M. Schmidt, C. R. Lewis, W. M. Jepsen, A. K. Håberg, T. Rundek, B. E. Levin, S. Hoscheidt, Y. Bolla, R. D. Brinton, N. J. Schork, M. Hay, C. A. Barnes, E. Glisky, L. Ryan & M. J. Huentelman. npj Aging and Mechanisms of Disease


Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance

To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svRT and PAL results were combined with 22 survey questions.

Analysis of svRT revealed education and stroke as potential modifiers of changes in processing speed and memory from younger to older ages (ntotal = 75,666, nwomen = 47,700, nmen = 27,966; ages 18–85 years old, mean (M)Age = 46.54, standard deviation (SD)Age = 18.40).

To complement this work, we evaluated complex visual recognition reaction time (cvrRT) in the UK Biobank (ntotal = 158,249 nwomen = 89,333 nmen = 68,916; ages 40–70 years old, MAge = 55.81, SDAge = 7.72). Similarities between the UK Biobank and MindCrowd were assessed using a subset of MindCrowd (UKBb MindCrowd) selected to mirror the UK Biobank demographics (ntotal = 39,795, nwomen = 29,640, nmen = 10,155; ages 40–70 years old, MAge = 56.59, SDAge = 8.16). An identical linear model (LM) was used to assess both cohorts. Analyses revealed similarities between MindCrowd and the UK Biobank across most results.

Divergent findings from the UK Biobank included (1) a first-degree family history of Alzheimer’s disease (FHAD) was associated with longer cvrRT. (2) Men with the least education were associated with longer cvrRTs comparable to women across all educational attainment levels.

Divergent findings from UKBb MindCrowd included more education being associated with shorter svRTs and a history of smoking with longer svRTs from younger to older ages.

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