Mitochondria regulate how neural stem cells become neurons during brain development. The findings may help explain how humans developed larger brains during evolution and how mitochondrial defects lead to some neurodevelopmental disorders.
Novelty directly activates the dopamine system and enhances associative learning. The findings have implications for the development of new machine learning technologies and educational strategies.
Bcl6 acts as a driver of neurogenic transition by directly silencing a selection of genes that belong to multiple extrinsic pathways promoting self-renewal. Bcl6 is only expressed in specific subsets of neurons and progenitor cells during brain development.
Using mouse models, researchers have developed a comprehensive map of the brain's immune cells. The study found microglia in the choroid plexus showed a similar activation state as microglia that come into contact with Amyloid deposits.
The phosphatase Prl-1 plays a key role in specifying where to form the highest density of synaptic connections on a neuron.
Mouse models and human brain tissue studies reveal microglia react to amyloid beta earlier in older females. Findings may provide avenues for the development of new drugs to help treat the neurodegenerative disease.
Hippocampal replay selectively enhances memory of highly rewarded locations in a familiar context.
A new study reports two different gut bacteria are depleted in people with depression, regardless of antidepressant treatments.
A new study reports amyloid precursor proteins modulate neural signal transmission by binding to a specific receptor. Researchers say modulating the receptor could help treat Alzheimer's disease.
