Vaccine hesitance waned over time, and the majority of caregivers and dependents with ASD received the COVID-19 vaccine following FDA approval. However, overall vaccine hesitancy influenced COVID-19 vaccine uptake in a minority of caregivers and dependents with ASD. Recent findings reveal that those on the autism spectrum are at greater risk of hospitalization following COVID-19 infection, and historically, a significant portion of parents of children with ASD are more likely to delay or decline any childhood vaccines.