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UC Irvine

·July 6, 2026·12 min read

Biomarkers Boost Antidepressant Success Rates by 67%

A new study demonstrates that combining fMRI brain connectivity, cognitive reward testing, and clinical markers to guide antidepressant selection increases patient response rates by nearly 67%.

Featured Genetics Neurology Neuroscience

·June 23, 2026·10 min read

World-First Embryonic Stem Cell Trial for Huntington’s Opens

UCI Health has launched the world's first in-human embryonic stem cell-derived trial for Huntington's disease, surgically implanting hNSC-01 neural stem cells deep into the striatum using real-time MRI guidance to protect, replace, and rebuild damaged brain circuits.

Featured Neurology Neuroscience

·April 23, 2026·7 min read

Dopamine Depletion: The Hidden Driver of Alzheimer’s Memory Loss

A new study identifies dopamine dysfunction in the entorhinal cortex as a central cause of Alzheimer’s memory impairment.

Featured Neurology Neuroscience

·October 6, 2025·6 min read

Brain’s Shape Could Reveal the Earliest Signs of Alzheimer’s

A groundbreaking study reveals that aging alters not just the size but the shape of the human brain, reshaping regions in ways linked to memory and reasoning decline. Researchers found that as people age, the lower and front areas of the brain expand outward, while the upper and back regions compress inward.

Featured Neurology Neuroscience

·August 9, 2025·4 min read

Natural Compound Combo Restores Aging Brain Cells

Scientists have identified a natural compound combination that reverses aging-related brain cell decline and removes harmful Alzheimer’s-linked proteins. The treatment, combining nicotinamide (vitamin B3) and the green tea antioxidant epigallocatechin gallate, restores guanosine triphosphate (GTP) levels—critical for neuronal energy and protein cleanup.

Featured Neuroscience Psychology

·March 19, 2025·5 min read

Early-Life Adversity Reshapes Brain Development and Behavior

Early-life adversity affects over half of children worldwide, increasing the risk of cognitive and mental health issues later in life. A new review highlights how unpredictable sensory experiences, beyond traditional stressors like abuse and neglect, can disrupt brain development.

Featured Neurology Neuroscience

·January 7, 2025·4 min read

Vascular Risk Factors Affect Brain Health Differently in Older People

A new study reveals that common cardiovascular conditions like high blood pressure and diabetes, known to damage brain blood vessels in younger populations, are not linked to increased brain vessel harm in individuals aged 90 and older. Researchers analyzed data from 267 participants in the National Institute on Aging’s 90+ Study and found no significant relationship between these risk factors and brain changes in this age group. Interestingly, blood pressure-lowering medications such as diuretics and beta blockers were associated with reduced risks of specific brain conditions, suggesting potential protective effects.

This shows a woman looking at a brain model.

Featured Neuroscience

·November 15, 2024·4 min read

Brain Circuits for Spatial Memory and Navigation Identified

Researchers have identified two neural circuits in the retrosplenial cortex (RSC) that are critical for spatial navigation and memory storage. The M2-projecting pathway links spatial thought to action, while the AD-projecting pathway supports location-specific memory.

Featured Neurology Neuroscience

·October 5, 2024·5 min read

New Molecule Offers Hope for Parkinson’s by Outperforming L-Dopa

A new study has discovered that ophthalmic acid, a molecule in the brain, acts like a neurotransmitter to regulate motor function, similar to dopamine. In Parkinson’s mouse models, this molecule improved movement for over 20 hours—far longer than the effects of the current treatment, L-dopa.

Featured Neuroscience

·May 14, 2024·5 min read

Sleep Apnea During REM Linked to Memory Decline

Sleep apnea events during REM sleep are linked to verbal memory impairment in older adults at risk for Alzheimer's disease. The research highlights the importance of focusing on sleep-stage-specific apnea severity for accurate diagnosis and treatment.

Featured Neuroscience Psychology

·May 14, 2024·4 min read

Dreams Dull the Distress of Emotional Memories

Dreaming helps prioritize and diminish the severity of emotionally charged memories. Participants who reported dreaming had better recall and were less reactive to negative images.

Featured Neuroscience

·April 10, 2024·4 min read

Hippocampus Generates Deep Sleep Waves

Scientists discovered a surprising new source for brain waves essential for deep sleep. These waves, traditionally thought to come from a different area, were also found to be generated by the hippocampus, a region crucial for memory.

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UC Irvine

Biomarkers Boost Antidepressant Success Rates by 67%

World-First Embryonic Stem Cell Trial for Huntington’s Opens

Dopamine Depletion: The Hidden Driver of Alzheimer’s Memory Loss

Brain’s Shape Could Reveal the Earliest Signs of Alzheimer’s

Natural Compound Combo Restores Aging Brain Cells

Early-Life Adversity Reshapes Brain Development and Behavior

Vascular Risk Factors Affect Brain Health Differently in Older People

Brain Circuits for Spatial Memory and Navigation Identified

New Molecule Offers Hope for Parkinson’s by Outperforming L-Dopa

Sleep Apnea During REM Linked to Memory Decline

Dreams Dull the Distress of Emotional Memories

Hippocampus Generates Deep Sleep Waves

Study Maps the 9 Distinct Types of Procrastinators

AI Chip Mimicking Brain’s Reflex Center Developed

Study Overturns Decades of External Axon Growth Theory

Study Shatters Assumptions About Brain Connectome Dynamics

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