Piezo1 limits the potential of regulatory T cells (Treg) to mitigate autoimmune neuroinflammation. Inhibiting Piezo1 could lead to new treatments for autoimmune disorders like multiple sclerosis.
Lower serum levels of the sugar metabolite GlcNAc was associated with progressive disability and neurodegeneration in patients with multiple sclerosis.
N-acetylglucosamine, a simple sugar found in breast milk, promotes remyelination in mouse models of multiple sclerosis. The findings could have implications for treating multiple sclerosis in humans.
Researchers link the rise in acute stress and depression rates in the U.S to multiple stressors, such as unemployment and coronavirus-related media consumption.
Quercetin, a flavonoid found in pickled capers, modulates potassium ion channels in the KCNQ gene family. These channels are influential in human health, and their dysfunction is linked to diseases, including diabetes, epilepsy, and cardiac arrhythmias.
Transplanting embryonic progenitor interneurons into the hippocampus of mouse models of TBI, researchers noticed the neurons migrated to the injury site and made new connections. Following treatment, memory improved and seizures were reduced.
Reducing the expression of the protein TOM1 in mouse models of Alzheimer's disease increased the pathology, exacerbated cognitive problems, and raised levels of inflammation in the brain. Restoring TOM1 reversed the effects. Findings suggest a new therapeutic target for treating dementia.
A newly identified neural network in the hippocampal formation plays a critical role in memory and object-location learning. The findings are highly relevant to learning and memory disorders, including Alzheimer's disease.
Living in a linguistically diverse environment helps promote more effective learning of new languages for monolingual people.
The brain's immune cells may contribute to the development of Alzheimer's disease. Turning off microglia in specific areas of the brain prevented the formation of amyloid plaques. The findings could help pave the way for new treatments for Alzheimer's.
Playing online games which are mentally taxing can help older adults to reduce cognitive decline associated with aging. Older adults who played brain training games showed similar brain functionality as younger people who were less practiced at the games.