Study reveals the role played by neuropathic pain in dendritic cells in the meninges via an increase in the metabolic kynurenine pathway. When the kynurenine pathway initiated by IDO1 was blocked, neuropathic pain was nullified.
Microbes in the gut influence what an animal chooses to eat. Altering the microbiome resulted in changes to preferred diets.
Gut microbes that metabolize tryptophan secrete indoles that stimulate the development of new neurons in the adult brain.
Normal sleep in mice is reliant upon bacteria that help produce neurotransmitters, such as serotonin, in the gut.
Researchers have uncovered the structure of psychedelic compounds when they actively bind to the 5-HT2A serotonin receptor on the surface of brain cells. The discovery could lead to the exploration of more precise compounds that offer the therapeutic effects of psychedelics for mental health disorders, but without the hallucinations.
High levels of anthranilic acid in the blood may be a new biomarker for assessing the risk of developing major depressive disorder.
Research examines the myths and science behind how the amino acid tryptophan, associated with turkey, affects mood.
A synthetic version of a fibupeptide, which is naturally produced by the microbiome, may help in the fight against antibiotic-resistant bacteria. Lugdunin has been shown to be effective against MRSA. The findings could help in the creation of a new class of antibiotics to treat infections currently resistant to drugs on the market.
Increased kynurenic acid production has been implicated in the pathology of schizophrenia. The findings provide a new target for cell-specific treatments that help reduce the production of kynurenic acid and reduce symptoms of schizophrenia.
A new study reveals a link between elevates microbiome levels of indole and hedonic eating. Researchers report those with higher levels of indole are more likely to have food addiction and overeating disorders.
Researchers pay tribute to Arvid Carlsson, who was awarded the Nobel Prize for his research into dopamine, and evaluate what his research means to modern neuroscience.
Researchers examine the role gut bacteria plays in the development of neurological disorders. Using mouse models of multiple sclerosis, researchers found compounds generated from the breakdown of tryptophan can cross the blood-brain barrier and activate anti-inflammatory pathways that limit neurodegeneration. Activation of these pathway have also been linked to Alzheimer's and brain cancers.
