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treatment resistant depression

·March 30, 2026·8 min read

Blocking NOX-1 Extends Ketamine’s Effectiveness for Depression

Researchers have identified the NOX-1 enzyme as the reason ketamine's antidepressant effects are short-lived. By blocking NOX-1, they extended the drug's benefits from days to weeks.

This shows a brain with wires coming out of it.

Featured Neuroscience Psychology

·March 28, 2026·11 min read

Can Deep Brain Stimulation Unlock Treatment-Resistant Depression?

Researchers are testing Deep Brain Stimulation (DBS) for treatment-resistant depression. By acting as a "brain pacemaker," the device targets white matter to help patients who haven't found relief from standard medications or therapy.

This shows PET scan images of the brain in response to ketamine.

Featured Neuroscience Psychology

·March 6, 2026·8 min read

Ketamine Restores Plasticity via AMPA Receptors

For the first time, scientists have visualized the molecular changes in the human brain that explain why ketamine works so quickly to treat depression.

Neuroscience

·February 28, 2026·7 min read

Ketamine Revolution: Study Redefines Depression Treatment

Pioneering research into ketamine has moved depression treatment away from slow-acting serotonin drugs toward rapid-acting glutamate therapy.

This shows a head with psychedelic images surrounding it, implying DMT's affect on resolving depression.

Featured Neuroscience Psychology

·February 17, 2026·9 min read

Single DMT Dose Provides Lasting Relief from Depression

A 25-minute "trip" for six months of relief? Researchers have found that the ayahuasca compound DMT provides a rapid, durable shield against depression.

Featured Genetics Psychology

·November 3, 2023·4 min read

New Gene Link to Treatment-Resistant Depression

Researchers discovered a gene, LHPP, that interacts with stress and plays a pivotal role in treatment-resistant Major Depressive Disorder (MDD) using an animal model. This groundbreaking study underscores the intricate dance between genetic risks and environmental factors in the onset of MDD.

Featured Neuroscience Psychology

·September 20, 2023·8 min read

Pioneering Biomarker for Resistant Depression Unearthed

Scientists have identified a unique biomarker in the brain that indicates recovery from treatment-resistant depression during deep brain stimulation (DBS). This significant discovery provides insights into DBS's effects on severe depression.

Featured Neuroscience Psychology

·December 14, 2022·5 min read

Patients With Treatment Resistant Depression at Higher Risk of Death

Study reveals people with treatment-resistant depression have a 23% higher risk of death than those without the condition.

Featured Neuroscience Psychology

·October 6, 2022·5 min read

Mechanism for the Antidepressant Effect of Ketamine Revealed

Those with treatment-resistant depression showed significant improvement in symptoms and became more receptive to positive experiences following a one-week ketamine treatment regimen.

This shows a brain and a finger shooting lightening out of it

Featured Neuroscience Open Neuroscience Articles Psychology

·November 22, 2021·8 min read

Novel Brain Stimulation Approach Treats Severe Depression

Combining deep-brain stimulation with intracranial EEG, researchers achieved an individualized understanding of specific brain networks that contributed to an individual's depression symptoms and identified stimulation patterns best suited to each patient for symptom relief.

This shows the researcher with the ECT machine

Featured Neuroscience Open Neuroscience Articles Psychology

·June 3, 2019·6 min read

Lower-amp ECT appears effective against suicidal thoughts

Low amplitude electroconvulsive therapy (ECT) lowers suicidal ideation in patients with major depressive disorder and bipolar depression, a new small randomized pilot study reveals. Within just three sessions, patients reported relief from suicidal thoughts.

image is a diagram of the dbs implants in the brain

Featured Neuroscience Psychology

·March 19, 2019·5 min read

Deep brain stimulation provides sustained relief for severe depression

Deep brain stimulation provides a significant reduction in the symptoms of depression for a number of patients with a treatment-resistant form of the disorder.