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TMPRSS2

Featured Genetics Neuroscience Open Neuroscience Articles

·August 25, 2020·3 min read

Scientists Prove SARS-CoV-2 Potential to Infect Human Brain Organoids

SARS-CoV-2, the virus responsible for COVID-19, can infect human neural progenitor cells and brain organoids. The findings back previous research, finding coronavirus can infect the human brain.

This is a drawing of a man in a facemask

Featured Genetics Neuroscience

·July 24, 2020·7 min read

How COVID-19 Causes Smell Loss

Infection of non-neuronal supporting cells in the nose and forebrain may be responsible for the olfactory problems associated with COVID-19. Findings suggest olfactory sensory neurons are not vulnerable to coronavirus infection as they do not express ACE2.

Featured Neuroscience Open Neuroscience Articles

·May 20, 2020·3 min read

COVID-19 cytokine storm: Possible mechanism for the deadly respiratory syndrome

SARS-CoV-2, the virus responsible for COVID-19, enters human cells by attaching to ACE2 and utilizing TMPRSS2. Drugs that block ACE2 or inhibit the enzyme could help treat the coronavirus, but only during early infection. As the infection progresses, SARS-CoV-2 becomes engulfed in human cells, reducing the number of ACE2 receptors on a cell and leading to an increase of angiotensin II in the blood. Angiotensin II triggers an inflammatory pathway, providing a positive feedback cycle, named IL-6 amplifier, resulting in excessive immune activation and the cytokine storm associated with severe COVID-19.

Featured Neuroscience Open Neuroscience Articles

·May 13, 2020·6 min read

Cats can become infected with and may transmit COVID-19 to other cats

Study confirms cats can become infected with SARS-CoV-2, the virus that causes coronavirus and pass the infection along to other cats. Cats shed the virus up to six days following infection via their nasal passages. Researchers urge cat owners to keep their pets indoors during the pandemic.

Featured Neuroscience

·May 12, 2020·2 min read

Exploring why some COVID-19 patients lose their sense of smell

ACE2 and TMPRSS2, two proteins required for SARS-CoV-2 entry, are produced in cells in the nasal cavity that contribute to odor detection. The findings may explain why people with coronavirus often describe the loss of the sense of smell as a symptom of the virus.

Featured Neuroscience

·April 23, 2020·5 min read

Key nose cells identified as likely COVID-19 virus entry points

The receptor protein ACE2 and the TMPRSS2 protease that can activate SARS-CoV-2 entry are expressed in cells on the inner lining of the nose. Mucus producing goblet cells and ciliated cells in the nose have the highest levels of both proteins, making them the most likely initial infection route for coronavirus. Additional key entry points were found in the cells of the eye's cornea and the intestines. This suggests other points of infection could be via the tear ducts and through fecal-oral transmission.

Featured Neuroscience Open Neuroscience Articles

·April 23, 2020·4 min read

Evidence suggests COVID-19 isn’t sexually transmitted

Previous studies report COVID-19 may be present in the testes. Researchers report coronavirus is unlikely to spread via semen, and the chances of the infection being spread through sexual transmission are remote.

Featured Genetics Neuroscience Open Neuroscience Articles

·April 22, 2020·7 min read

Cells in lungs, nasal passage, and intestines more susceptible to COVID-19 infection

Researchers have identified specific cell types that appear to be the main targets of SARS-CoV-2, the virus that causes COVID-19. Using existing data on the RNA found in different types of cells, researchers were able to identify cells that expressed ACE2 and TMPRSS2, two proteins that assist coronavirus to enter human cells. Cells in the lungs, nasal passage and intestines appear to be the main targets for SARS-CoV-2.

Featured Genetics Neuroscience

·April 7, 2020·5 min read

Coronavirus receptor abundantly expressed in certain progenitor cells

Certain progenitor cells in the bronchi are mainly responsible for producing coronavirus receptors. These cells normally develop into respiratory tract sells linked with cilia, that clear bacteria out of the lungs.

Featured Neuroscience Neuroscience Videos Open Neuroscience Articles

·March 6, 2020·3 min read

Potential drug to block coronavirus identified

A clinically proven drug known to block an enzyme essential for the viral entry of Coronavirus into the lungs blocks the COVID 19 (SARS-CoV-2) infection. The drug, Camostat mesilate, is a drug approved in Japan to treat pancreatic inflammation. Results suggest this drug may also protect against COVID 19. Researchers call for further clinical trials.

TMPRSS2

Scientists Prove SARS-CoV-2 Potential to Infect Human Brain Organoids

How COVID-19 Causes Smell Loss

COVID-19 cytokine storm: Possible mechanism for the deadly respiratory syndrome

Cats can become infected with and may transmit COVID-19 to other cats

Exploring why some COVID-19 patients lose their sense of smell

Key nose cells identified as likely COVID-19 virus entry points

Evidence suggests COVID-19 isn’t sexually transmitted

Cells in lungs, nasal passage, and intestines more susceptible to COVID-19 infection

Coronavirus receptor abundantly expressed in certain progenitor cells

Potential drug to block coronavirus identified

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