Fentanyl enhances direct pathway medium spiny neurons activity in the striatum. During withdrawal from the opioid, inhibitory signals from direct pathway medium spiny neurons to dopaminergic neurons become enhanced. The enhanced suppression of dopaminergic neurons contributes to the negative emotions associated with fentanyl withdrawal. Inhibiting the direct pathway medium spiny neurons can reduce withdrawal symptoms and associated anxiety behaviors.
Researchers identify the role the Pig-Q gene plays in sleep regulation. Mutations of the Pig-Q gene increase sleep.
Transplanting intestinal epithelial stem cells from healthy donors reduced stroke-induced mortality, decreased the volume of dead brain tissue and gut leakiness, and prevented stroke-induced cognitive decline.
Researchers report bone fractures in those with Down syndrome are unlikely to fully heal.
Appreciating the beauty in the smaller things in everyday life can contribute to a more meaningful existence, a new study reports.
A new study sheds light on how the neocortex in the human brain develops.
Exposure to extremely high microwave and radio frequencies may result in high stresses within the brain, researchers say.
Spending time enjoying the great outdoors improves both physical and mental health. Researchers say more interventions need to be taken to get people to spend time enjoying nature.
Study reveals significant changes in the expression of multiple genes in the placenta associated with exposure to UFP air pollution. Additionally, researchers reported noticeable reductions in fetal and placental length, and fetal weight in those with low dose UFP exposure.
Heavy cannabis use in women is associated with reduced risk of developing diabetes, a new study reveals.
Neurosteroid replacement therapy may provide relief of symptoms for new mothers suffering from postpartum depression.
A new STING treatment induces immunological responses that allow the immune system to fight otherwise immunological resistant glioblastoma cancer cells, researchers report.