A brain organoid study reveals how a genetic mutation associated with Pitt-Hopkins syndrome, a profound form of autism, disrupts neural development. Using gene-editing technology, researchers recovered the function of the TCF4 gene and effectively restored neural structure and function.
Breathing difficulties associated with Pitt Hopkins syndrome, a rare form of autism, have been linked to a specific set of neurons in the brainstem.
Postmortem study reveals those with ASD have cellular abnormalities that impair the production of myelin.
TCF4 may serve as a master regulator of a gene network dysregulated in schizophrenia at the early stages of neurodevelopment.
Researchers have developed a potential treatment for Pitt-Hopkins syndrome, an autism spectrum disorder.
A neuron’s fate was thought to be determined by the timing of its birth date. Neuroscientists recently showed that there is a distinct stem cell progenitor that gives rise to upper layer neurons, regardless of birth date or place.