Researchers have identified a new biomarker for psychosis in the striatal dopamine neurons. Those at risk for psychosis showed increased activation in the striatum for positive feedback and decreased activation when faced with negative feedback.
A cluster of epigenetic marks in an enhancer at IGF2 could enhance dopamine synthesis associated with psychosis in schizophrenia and bipolar disorder. The findings may help in devising more effective treatments and screening strategies for both disorders.
A new study reveals people with schizophrenia have a disrupted stress response. Researchers report those with schizophrenia have an increase in dopamine release in the striatum, but not in the prefrontal cortex, in response to stress.
New research could lead to new treatment strategies for the underlying causes of schizophrenia.
