Increased sensitivity in the locus coeruleus-norepinephrine system in the brain drives the development of anxiety in depression. The findings shed new light on the neurobiological mechanisms behind stress resilience.
S1PR3, a receptor found on the surface of brain cells, may play a key role in stress resilience. Veterans with severe PTSD symptoms had lower levels of the S1PR3 protein in their blood than peers without the disorder.
