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spiny projection neurons

·July 22, 2020·6 min read

Neural Vulnerability in Huntington’s Disease Tied to Release of Mitochondrial RNA

In both human cell and mouse models of Huntington's disease, RNA from mitochondria was misplaced within spiny projection neurons. The stray RNAs, which looked different to cells than RNA derived from the cell nucleus, trigger an immune reaction that can lead to striatal cell type vulnerability.

Featured Neurology Neuroscience

·January 31, 2020·5 min read

New light shed on neuronal circuits involved in behavior, learning and dysfunction

New findings about dopaminergic neurons in the striatum could have implications for treating Parkinson's disease and Tourette syndrome.

Featured Neurology Neuroscience

·May 17, 2018·6 min read

How the Brain Orchestrates Movement

Researchers shed light on what happens to specific neurons when neurodegenerative diseases impact movement. The findings could help in the development of new treatments for Parkinson's and Huntington's disease.