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Rett Syndrome

·December 16, 2024·6 min read

Protein Loss Triggers Molecular Changes Linked to Rett Syndrom

Researchers have uncovered how loss of the MeCP2 protein triggers early molecular changes leading to Rett syndrome, a severe neurological disorder. By studying adult mice, they demonstrated that MeCP2 loss disrupts gene expression well before measurable neurological deficits arise.

Autism Brain Cancer Featured Neuroscience

·July 25, 2024·8 min read

Cancer Drug Shows Promise for Autism Cognitive Function

A new experimental cancer drug could ease cognitive difficulties for those with Rett syndrome, a rare autism-linked disorder, by enhancing brain cell functions. The drug, ADH-503, improves the activity of microglia, which are crucial for maintaining neural networks.

Featured Genetics

·July 22, 2020·6 min read

Proteins, and Labs, Coming Together to Prevent Rett Syndrome

Findings about the distribution of condensates in Rett syndrome shed light on how cells compartmentalize chromosomes and provide new insights into potential paths of therapies for the neurodevelopmental disorder.

Featured Genetics Neuroscience

·January 8, 2020·4 min read

Abnormal neuron activity manifests as parental neglect

Abnormal activation of parvalbumin neurons in the young mouse auditory cortex manifests as a result of maternal neglect.

Autism Featured Neuroscience Open Neuroscience Articles

·July 24, 2019·5 min read

Pupil dilation and heart rate, analyzed by AI, may help spot autism early

A machine learning algorithm can accurately detect abnormalities in pupil dilation, which are predictive of ASD, in mouse models. The AI can also detect if a female has Rett syndrome with 80% accuracy. The system could be used to detect autism in infants and toddlers.

Many neurostem cells, nuclei and astrocytes are shown mixed together.

Featured Genetics Neuroscience

·March 5, 2019·4 min read

Discovery of the Genetics Conductor of Brain Stem Cells

Researchers describe their findings about how the Foxg1 gene is involved in the development and differentiation of neurons and glial cells from stem cells.

Featured Genetics Neuroscience Open Neuroscience Articles

·February 20, 2019·3 min read

Genetic Mechanism Involved in How Females Inherit Traits Identified

Researchers have identified a specific mechanism involved in how females inherit traits. The findings could help reduce susceptibility to Fragile X and Rett syndrome, the researchers report.

Autism Featured Genetics Neuroscience Open Neuroscience Articles

·January 29, 2018·4 min read

Researchers Reverse Symptoms in Rett Syndrome Model

Activating neurons in the medial prefrontal cortex can reverse breathing and memory abnormalities in mouse models of Rett syndrome, researchers report.

Autism Featured Genetics Psychology

·January 5, 2018·6 min read

X Chromosome Reactivation Could Treat Rett Syndrome and Other X-Linked Disorders

Mass General researchers have developed a strategy for treating disorders related to the X chromosome.

Featured Genetics Psychology

·September 26, 2016·5 min read

Gene Regulation in Brain May Explain Repetitive Behaviors in Rett Syndrome Patients

A new study reports a protein associated with Rett syndrome is also among a group of three proteins that affect the function of a gene previously linked to OCD.