Dopamine in the cerebellum helps regulate social behaviors via its action on D2 receptors. Changes in D2 levels in Purkinje cells alter sociability and preference for social novelty without affecting motor function.
Axonal swelling in the Purkinje cells of mice had no detrimental impact on firing rate or the speed at which axons transmit signals. At peak firing rate, axons with swellings were less likely to fail than those without.
Findings shed new light on how the brain wires during development.
Acute inflammation of the anterior cerebellum resulted in depression-like symptoms in rodent models. Suppressing microglia helped reduce hyperexcitability and symptoms of depression.
In mice genetically engineered to carry human stuttering mutations, vocalization defects are derived from abnormalities in astrocytes in the corpus callosum.
Mouse study reveals neonatal nicotine exposure primes the ventral tegmental area, making the animals more susceptible to the effects of nicotine when exposed again later in life.
Findings provide evidence to support the role of human roseoloviruses, HHV-6A, and HHV-6B in bipolar disorder and major depressive disorder.
Researchers discover higher infection rates in Purkinje cells with the herpesvirus HHV-6 in patients with bipolar disorder.
Computational neurosciences have created a virtual version of Purkinje cells in the brain's cerebellum. The virtual cells may shed light on how Purkinje cells work.
Researchers report the ANKRD16 can prevent protein aggregates associated with neurodegenerative diseases.
A new study sheds light on how the cerebellum is able to make predictions and learn from mistakes, especially when it comes to completing complex motor actions. The findings could help in the development of new machine learning technologies.
Gene expressions in the brain that occur early in development may explain why some cerebellar stem cell populations behave differently in people with SCA1, researchers report.
