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          psilocybin

          This shows a person sitting and mushrooms.
          FeaturedNeurologyNeuroscience
          ·April 30, 2025·6 min read

          Psilocybin Shows Promise for Parkinson’s Mood and Motor Symptoms

          A new pilot study reveals that psilocybin—the compound found in psychedelic mushrooms—may significantly improve mood, cognition, and motor function in people with Parkinson’s disease. The compound was well tolerated, with only mild side effects, and benefits persisted for weeks after dosing. While the study was primarily designed to test safety, researchers observed meaningful and lasting improvements in multiple symptoms.
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          This shows people and mushrooms.
          FeaturedNeurosciencePsychology
          ·April 22, 2025·4 min read

          More People Turning to Psilocybin for Self-Treatment

          Psilocybin use in the U.S. has risen sharply across all age groups since 2019, coinciding with increasing legalization and interest in its therapeutic potential. A new study reveals a 44% rise in past-year use among young adults and a 188% increase among those over 30.
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          This shows a woman and mushrooms.
          FeaturedNeurosciencePsychology
          ·April 4, 2025·3 min read

          How Psilocybin Lifts Mood Without the Hallucinogenic Trip

          Researchers have uncovered two key brain mechanisms—specific neurons and a serotonin receptor—that help explain how psilocybin produces long-lasting antidepressant effects. Their study identified pyramidal tract neurons in the medial frontal cortex and the serotonin 5-HT2A receptor as essential to the therapeutic action of psilocybin.
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          This shows a happy person surrounded by psychedelic swirls.
          FeaturedNeurosciencePsychology
          ·October 8, 2024·3 min read

          Optimism Boosted by Psilocybin, Hinting at Depression Relief

          Researchers have discovered that psilocybin, a psychedelic compound in magic mushrooms, increases optimism and motivation in rats, suggesting potential therapeutic benefits for treating depression. Using computational modeling, scientists observed that rats given psilocybin were more likely to engage in reward-based tasks, indicating enhanced optimism.
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          This shows a woman looking in a mirror.
          FeaturedNeurosciencePsychology
          ·September 24, 2024·2 min read

          Psilocybin Shows Promise in Treating Body Dysmorphic Disorder

          A new study reveals that psilocybin, the active compound in magic mushrooms, may help treat body dysmorphic disorder (BDD) by altering brain connectivity. In a pilot trial, patients with BDD showed significant improvements in symptoms after a single dose of psilocybin, with brain scans indicating increased neural flexibility. Though preliminary, the study suggests that psilocybin could offer new hope for BDD sufferers. Larger studies are needed to confirm its efficacy.
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          This shows a head and psychedelic swirls.
          FeaturedNeurosciencePsychology
          ·September 22, 2024·7 min read

          Psilocybin Shows Greater Long-Term Benefits Over SSRI for Depression

          A study comparing psilocybin to the SSRI escitalopram found both drugs improved depressive symptoms similarly over six months, but psilocybin offered additional psychosocial benefits. Patients taking psilocybin reported a greater sense of meaning, psychological connectedness, and improved social functioning. These results suggest psilocybin could provide a more holistic treatment option for depression, addressing both symptoms and overall well-being. While promising, psilocybin remains experimental and is only administered in controlled environments.
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          This shows a woman.
          FeaturedNeurosciencePsychology
          ·August 21, 2024·3 min read

          High-Dose Psilocybin Shows Potential as an Antidepressant Treatment

          A meta-analysis suggests that high doses of psilocybin may alleviate depressive symptoms similarly to the SSRI drug escitalopram. While the effect size was small, psilocybin outperformed placebo in clinical trials, though study design flaws could have led to overestimated results. The findings indicate that psilocybin, particularly in high doses, may offer a new avenue for treating depression, comparable to existing antidepressants.
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          This shows gummies.
          FeaturedNeuroscience
          ·July 18, 2024·3 min read

          Brain-Boosting Gummies May Contain Illegal Hallucinogens

          Researchers warn that mushroom gummies sold to boost brain function may contain illegal hallucinogens and other harmful ingredients, after five people, including a 3-year-old, fell ill. Testing revealed that three out of five brands contained psilocybin or psilocin, Schedule I drugs, which were not listed on the labels. This poses a public health threat, as consumers are unaware of what they are ingesting.
          Read More
          This shows a psychedelic brain.
          FeaturedNeurosciencePsychology
          ·July 17, 2024·5 min read

          Mind-Bending: Psilocybin Reshapes Brain Networks for Weeks

          A new study reveals that psilocybin, the active compound in magic mushrooms, temporarily disrupts brain networks involved in introspective thinking, like daydreaming and memory. These changes persist for weeks, potentially making the brain more flexible and improving mental health. The findings could pave the way for psilocybin-based therapies for depression and PTSD. The research underscores the importance of using these drugs under medical supervision.
          Read More
          This shows a woman and mushrooms.
          FeaturedNeuroscience
          ·May 24, 2024·6 min read

          Psilocybin Induces Brain Hyperconnectivity, Enhancing Mystical Experiences

          Psilocybin, the active compound in magic mushrooms, initiates a pattern of dynamic hyperconnectivity in the brain. This brain state is linked to the ego-modifying effects and feelings of oceanic boundlessness commonly reported during psychedelic experiences.
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          This shows a woman and mushrooms.
          FeaturedNeurosciencePsychology
          ·May 13, 2024·3 min read

          Psilocybin Shows Promise in Anorexia Treatment

          A new study highlights the potential of psilocybin, found in magic mushrooms, as a treatment for anorexia nervosa (AN), a psychiatric disorder with one of the highest mortality rates. The research demonstrated that psilocybin enhances cognitive flexibility and body weight maintenance in an animal model of AN.
          Read More
          This shows a woman and mushrooms.
          FeaturedNeurosciencePsychology
          ·May 2, 2024·7 min read

          Psilocybin Effective as Antidepressant

          Psilocybin, the psychoactive compound in magic mushrooms, is notably more effective at alleviating depression symptoms than conventional controls. Analyzing seven trials with 436 participants, researchers found a substantial improvement in depression scores following psilocybin treatment compared to placebos or other minor psychedelic doses, showcasing a large effect size.
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          This shows an older man and a brain.

          Overall Brain Health Protects Memory From Early Alzheimer’s

          This shows a person in a wheelchair and neurons.

          SCI Redefined as a Broken Brain–Body–Environment Loop

          This shows the Axo-axonic connection network.

          Axo-Axonic Synapses Drive Split-Second Fly Escape Reflexes

          This shows an axon.

          Novel Antibody Repairs Acute Spinal Cord Lesions

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