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protein misfolding

Featured Genetics Neurology Neuroscience

·December 4, 2023·4 min read

The Role of Protein Misfolding in Neurodegenerative Diseases

Neurodegenerative diseases share a common factor: protein misfolding and deposits in the brain. Misfolded proteins can lead to toxic activity or the loss of the protein's physiological function, causing damage to neurons.

Featured Genetics Neuroscience Open Neuroscience Articles

·September 8, 2021·5 min read

Aging: It’s More Complicated Than We Thought

A new study on aging reveals a surprising discovery about the connection between protein shape and mitochondrial health.

Electrophysiology Featured Neuroscience Open Neuroscience Articles

·August 19, 2021·5 min read

Flawed Quality Control in the Brain

A new mouse line makes the state of protein balance visible in the mammalian brain for the first time, allowing researchers to investigate disorders associated with protein misfolding.

Featured Genetics Neurology Open Neuroscience Articles

·August 23, 2020·4 min read

Unique Protein Structures Could Hold the Key to Parkinson’s Disease

Researchers have discovered a series of misfolded alpha-synuclein protein structures never previously observed. The alpha-synuclein fibers were larger than previously reported and adopted a striking variety of shapes. The work lays the foundation for a detailed analysis of misfolded alpha-synuclein structures and could provide a better understanding of the neurobiology of Parkinson's disease.

Image shows the worm's protein folding network.

Featured Genetics Neurology

·September 8, 2016·7 min read

Can Some Types of Fat Protect Us From Brain Disease?

According to researchers, having a little extra fat may help protect against Alzheimer's, Parkinson's and other neurodegenerative diseases.

Featured Genetics

·May 23, 2016·4 min read

Untangling Disease Related Protein Misfolding

Researchers report how a key protein in the blood coagulation pathway folds to a higher energy state.

The image shows the molecular chaperone binding to amyloid beta.

Featured Genetics

·February 17, 2015·5 min read

Molecular Inhibitor Breaks Cycle That Leads to Alzheimer’s

A new study reports a molecular chaperone can inhibit a key stage in the development of Alzheimer's disease.

The image shows the nucleus of a cell in blue. It is adjacent to the rough endoplasmic reticulum in green.

Featured Genetics

·September 11, 2014·3 min read

Cells Put off Protein Production During Times of Stress

A new study could provide additional insights into neurodegenerative diseases which result from misfolded proteins piling up.

This is a drawing of a fruit fly with z's coming out of its mouth, as if it were snoring.

Featured Neuroscience

·February 20, 2014·3 min read

Study in Fruitflies Strengthens Connection Among Protein Misfolding, Sleep Loss, and Age

Researchers investigate the molecular mechanisms underpinning sleep.

The image shows cells stained from this experiment.

Featured Neurology Open Neuroscience Articles

·December 11, 2013·4 min read

Sleep-Deprived Mice Show Connections Among Lack of Shut-eye, Diabetes and Age

Sleep deprivation could contribute to the dysfunction of pancreatic cells. These functions may be exacerbated by aging, a new study reports.

The image shows slides from the research. The caption best describes the image.

Featured Neurology Open Neuroscience Articles

·September 25, 2013·2 min read

New Mechanism for Protein Misfolding Could Link to ALS

Researchers find the amino acid, BMAA, can be inserted into neuroproteins. This causes them to misfold and aggregate. BMAA has been detected in the brains of those with ALS.

The image shows prefoldin protein expression in mice.

Featured Neurology

·July 12, 2013·2 min read

Fighting Alzheimer’s Disease with Protein Origami

Researchers find the human protein prefoldin can reduce neurotoxicity in the clumps of beta-amyloid which collects in the brains of Alzheimer's patients.

protein misfolding

The Role of Protein Misfolding in Neurodegenerative Diseases

Aging: It’s More Complicated Than We Thought

Flawed Quality Control in the Brain

Unique Protein Structures Could Hold the Key to Parkinson’s Disease

Can Some Types of Fat Protect Us From Brain Disease?

Untangling Disease Related Protein Misfolding

Molecular Inhibitor Breaks Cycle That Leads to Alzheimer’s

Cells Put off Protein Production During Times of Stress

Study in Fruitflies Strengthens Connection Among Protein Misfolding, Sleep Loss, and Age

Sleep-Deprived Mice Show Connections Among Lack of Shut-eye, Diabetes and Age

New Mechanism for Protein Misfolding Could Link to ALS

Fighting Alzheimer’s Disease with Protein Origami

Memory Rewritten: Study Finds No Clear Line Between Episodic and Semantic Retrieval

Brain Stimulation Method Can Evaluate Consciousness in Alzheimer’s Disease

Early Intervention Helps Most Autistic Children Acquire Spoken Language

Brain Conductors Find Precise Connection to Target Cells via Protein Handshake

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