p11, a protein implicated in serotonin function, affects the initial release of cortisol in mice by modulating the activity of specific neurons in the hypothalamus. Previous studies found people with depression lave lower levels of p11 in their brains. The findings could help in the development of new treatments for depression and stress.
Researchers explain how a molecular amplification system helps a new class of antidepressants alter brain signaling in specific neurons and how this produces the antidepressant effect.
Researchers have devised a way to create snapshots of gene expression in neurons based on their connections.