Researchers have identified 579 genetic loci associated with increased risk of disorders associated with self-regulation disorders including addiction, ADHD, and anti-social behavior.
Opioid use disorder affects genes associated with proinflammatory immune molecule encoding and genes associated with remodeling the extracellular matrix, suggesting the connection between neurons may be altered as a result of opioid use. Additionally, those with OUD have higher levels of microglia in the brain.
Neuroinflammation may be a key player in the pathological brain changes produced as a result of chronic opioid use. Microglia is likely responsible for the majority of the changes.
Animal studies and analysis of human data reveal a link between vitamin D deficiency and an increased risk of both opioid addiction and sun-seeking behaviors.
A newly developed experimental vaccine can diminish the fatal respiratory effects of carfentanil and fentanyl in rodent models.
Altered expression of FYN, a gene associated with the production of Tau, was identified in the brains of people addicted to heroin. Findings suggest opioid use can affect the brain in a way that might cause vulnerability in neural systems that can trigger neurodegeneration later in life.
Researchers administered antibiotics to rats for two weeks, depleting their gut microbiome. They then administered oxycodone. Compared to rats given only the opioid, those given the antibiotics had profound changes in how their brains responded to the pain killers.
Using chemogenetic methods, researchers activated neurons in the anterior insular and increased prosocial behavior in rodent models of opioid addiction.
Study reveals 412 counties, mainly in the Midwest and South, are at the highest risk of opioid deaths in the US. Researchers propose new strategies for improving treatment for opioid addiction.