New research highlights how ayahuasca’s long-term mental health outcomes depend heavily on individual mental health history and the environment in which it is used. While the psychedelic has shown promise in easing anxiety and depression, adverse mental states—such as feelings of disconnection or hopelessness—were more common among users with pre-existing conditions or those in unsupportive, non-traditional settings. Interestingly, some negative experiences, like visual distortions, were linked to positive outcomes later on, suggesting that so-called adverse effects may hold therapeutic value.
