Researchers have identified a specific rearrangement involving the NF2 gene that appears to cause radiation induced meningiomas. The Nature Communication study reports this mutation could be a basis for why many long term pediatric cancer survivors go on to develop brain tumors later in life.
Researchers from the University of Plymouth have discovered the tole PrPC plays in the development of neurofibromatosis 2 tumors. According to the study, the prion protein is overproduced in schwannomas, compared with healthy Schwann cells. This overproduction is a result of Merlin deficiency and contributed to tumor growth in NF2 patients.
Researchers identify the role of the tumor suppressor Merlin in regulating the integrity of axons. Damage to the axons may result in peripheral neuropathy.
Researchers discover the genetic landscape of the most common form of brain tumor can be explained by abnormalities in five genes. The finding could help to develop personalized medical therapies and treatment options.
Johns Hopkins scientists hope discovery will drive drug treatments. Johns Hopkins researchers say they have discovered one of the most...