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neuropharmacology

·November 17, 2025·6 min read

Animal-Free Brain Tissue Breakthrough Could Transform Drug Testing

Researchers have created functional brain-like tissue without relying on any animal-derived materials, marking a major step toward more ethical and reproducible neurological research. By transforming a chemically inert polymer (PEG) into a porous, maze-like scaffold, scientists enabled donor brain cells to organize into active neural networks.

Featured Neuroscience

·November 17, 2025·9 min read

How Mounjaro Alters Craving Circuits in the Brain

A rare intracranial brain-recording study revealed that tirzepatide, a GLP-1 and GIP receptor agonist, temporarily silences craving-related neural activity in a key reward circuit of the brain. Using implanted electrodes in a patient with treatment-resistant obesity and loss of control eating, researchers observed that the drug initially shut down signaling in the nucleus accumbens.

Featured Neurology Neuroscience

·November 12, 2025·5 min read

Alzheimer’s Drug Reduces Amyloid but Fails to Restore Brain Waste Flow

Researchers found that lecanemab, the Alzheimer’s drug designed to clear amyloid-β plaques, does not improve the brain’s waste clearance system in the short term. In a three-month study using MRI-based DTI-ALPS imaging, scientists observed no measurable recovery in glymphatic function after treatment.

This shows a man holding a wine glass against a psychedelic backdrop.

Featured Neuroscience

·November 10, 2025·4 min read

Psychedelics Calm Stress Circuits to Reduce Alcohol Drinking

New research shows that psilocin, the active metabolite of the psychedelic psilocybin, may reduce alcohol consumption by calming stress-sensitive neurons in the central amygdala. In female mice exposed to long-term alcohol use, psilocin dampened the hyperactivity of these neurons, temporarily reducing drinking.

Featured Neurology Neuroscience Pain

·November 7, 2025·5 min read

Nano Tech Helps CBD Quiet Pain at the Source

A new study shows that CBD delivered through a nano-micelle system can cross the blood–brain barrier and produce rapid neuropathic pain relief. The formulation, called CBD-IN, helped mice within 30 minutes and avoided the motor and cognitive side effects often seen with conventional pain drugs.

Brain Cancer Featured Neurology Neuroscience

·October 29, 2025·6 min read

How Chemotherapy Triggers Nerve Damage, and How to Stop It

A new study reveals that chemotherapy-induced nerve pain arises from a stress response in immune cells that triggers inflammation and neurotoxicity. Researchers found that activating a cellular stress sensor called IRE1α causes nerve damage and pain during chemotherapy, but blocking it prevents both in mice.

Featured Neuroscience Psychology

·October 28, 2025·7 min read

Dopamine Boost Makes People More Patient

In one of the largest studies of its kind, researchers found that increasing dopamine levels with L-DOPA made people slightly more willing to wait for larger, delayed rewards—reducing impulsive decisions by about 20%. The study challenges earlier research suggesting that dopamine increases impulsivity, showing instead that it promotes patience and long-term thinking.

Featured Neuroscience Psychology

·October 27, 2025·4 min read

Psychedelics May Rewire Memory Circuits Key to Mental Health

New research suggests that psychedelic drugs may work by strengthening specific brain connections linked to memory and cognition. Scientists found that under psychedelic exposure, neurons in the claustrum—a region dense with psychedelic-sensitive receptors—intensified their communication with the anterior cingulate cortex, a region involved in mood and psychiatric disorders.

Featured Neurology Neuroscience

·October 14, 2025·6 min read

Pregnancy Hormones Show Promise in Treating Progressive MS

Researchers have identified two forms of estrogen, estradiol and estriol, that may reduce inflammation and protect nerve fibers in progressive multiple sclerosis (MS). Using a virus model of the disease, the study found that both hormones lowered spinal cord inflammation, while estradiol significantly preserved the myelin sheath that protects nerve cells.

Brain Cancer Featured Neurology Neuroscience

·October 13, 2025·6 min read

Lymphatic Damage Tied to Chemo Brain Fog

New research reveals that chemotherapy may cause “chemo brain” by damaging the brain’s lymphatic system — the network responsible for clearing waste and supporting immune function. Using mouse models and human-engineered tissues, scientists found that common drugs like docetaxel shrink lymphatic vessels and impair drainage, leading to memory deficits and cognitive decline.

Featured Neurology Neuroscience

·October 9, 2025·8 min read

Compound Could Repair Nerve Damage in Multiple Sclerosis

Researchers have identified two compounds capable of repairing the protective myelin sheath damaged by multiple sclerosis, a major advance toward reversing nerve injury rather than just slowing it. The lead compound, K102, not only promotes remyelination but also balances immune function—key for long-term neurological recovery.

Featured Neurology Neuroscience

·October 7, 2025·6 min read

Tiny Peptide Shows Powerful Brain Healing After Traumatic Injury

A small peptide called CAQK, composed of just four amino acids, has shown remarkable neuroprotective effects in mouse and pig models of traumatic brain injury. When injected intravenously, CAQK travels directly to damaged brain tissue, where it binds to overexpressed proteins and reduces inflammation, cell death, and tissue damage.

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neuropharmacology

Animal-Free Brain Tissue Breakthrough Could Transform Drug Testing

How Mounjaro Alters Craving Circuits in the Brain

Alzheimer’s Drug Reduces Amyloid but Fails to Restore Brain Waste Flow

Psychedelics Calm Stress Circuits to Reduce Alcohol Drinking

Nano Tech Helps CBD Quiet Pain at the Source

How Chemotherapy Triggers Nerve Damage, and How to Stop It

Dopamine Boost Makes People More Patient

Psychedelics May Rewire Memory Circuits Key to Mental Health

Pregnancy Hormones Show Promise in Treating Progressive MS

Lymphatic Damage Tied to Chemo Brain Fog

Compound Could Repair Nerve Damage in Multiple Sclerosis

Tiny Peptide Shows Powerful Brain Healing After Traumatic Injury

Prenatal Lead Exposure Affects the Aging Brain

Uncanny Average: Most People Can No Longer Spot an AI Face

Predicting Autism Traits Through Infant Sleep

New Bio-Implant for Spinal Cord Repair

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