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nanotech

·February 18, 2025·5 min read

Nanoparticles Deliver mRNA to the Brain, Bypassing Blood-Brain Barrier

Scientists have developed a lipid nanoparticle system that enables mRNA to cross the blood-brain barrier, a long-standing challenge in neuroscience. In studies using mice and human brain tissue, these nanoparticles successfully delivered therapeutic mRNA, opening doors for potential treatments for neurological diseases like Alzheimer’s, ALS, and brain cancer.

Featured Genetics Neuroscience

·December 17, 2024·6 min read

Brain-Targeted mRNA Delivery Breaks the Blood-Brain Barrier

Researchers have developed lipid nanoparticles (LNPs) that cross the blood-brain barrier (BBB) and precisely target brain cells, a major step toward treating neurological diseases like Alzheimer’s. By attaching short peptides to LNPs, scientists achieved targeted mRNA delivery to neurons and endothelial cells, avoiding invasive procedures. Peptides are smaller, more stable, and easier to use than antibodies, making them ideal for LNP-based therapies.

Featured Neuroscience

·December 11, 2024·4 min read

New Materials Reduce Noise in Pacemakers, Enhancing Patient Comfort

Researchers developed innovative materials to improve the performance of brain and heart pacemakers by reducing signal interference. These devices often face challenges from external electromagnetic forces, causing discomfort like headaches for patients.

Featured Neuroscience Visual Neuroscience

·May 7, 2024·6 min read

Nano-Scale Vision Implant Promises New Hope for Blindness

Researchers developed a novel vision implant, featuring electrodes as small as a single neuron. This advanced technology, designed to interface directly with the visual cortex, could significantly enhance the visual perception in individuals who are blind.

Brain Cancer Featured Neurology Neuroscience

·May 6, 2024·6 min read

Nanoparticles Penetrate Blood-Brain Barrier to Treat Cancer

Researchers developed a novel nanoparticle that can cross the blood-brain barrier to target both primary breast tumors and brain metastases simultaneously. This dual-action approach utilizes a biodegradable polymer loaded with two prodrugs targeting cancer cell mitochondria.

Featured Neurology Neuroscience

·December 12, 2023·7 min read

Novel Nanoparticle Delivery System Targets Alzheimer’s Inflammation

A new study demonstrates a breakthrough in Alzheimer's disease (AD) treatment using lipid nanoparticles (LNPs) to deliver small interfering RNA (siRNA) to the brain's microglia. This approach effectively suppresses a protein linked to Alzheimer's-related inflammation.

Featured Neurology Neuroscience

·October 4, 2023·6 min read

Graphene Oxide Nanoflakes May Be A Potential Ally Against Alzheimer’s

Researchers explore graphene oxide nanoflakes as a promising tool in battling Alzheimer's disease, a devastating condition impacting over 40 million people globally. In a groundbreaking study, yeast cells accumulating harmful amyloid peptides linked to Alzheimer’s demonstrated recovery post-treatment with these nanoflakes.

Brain Cancer Featured Neuroscience

·March 7, 2023·7 min read

Revolutionary Brain Tumor Breakthrough Unveils Promising New Drug Treatments

In recent research, scientists have discovered that blood vessels feeding high-grade glioma brain tumors have high levels of LDL receptors (LDLR) on them. The study found that using drug-containing nanoparticle-based therapies to target these receptors can be a new way of treating cancer. Gliomas are the most common primary brain tumors and, due to their highly aggressive nature, have a poor prognosis with an average survival of only 4.6 months without treatment and approximately 14 months with optimal multimodal treatments. This research could pave the way for treating glioma brain tumors with LDL receptor-targeted nanoparticle-based therapies, thereby cutting off the energy supply of cancer cells.

Featured Genetics Neurology Neuroscience

·January 20, 2023·4 min read

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer's disease.

This shows the nanoparticles entering the retina

Featured Genetics Neuroscience Visual Neuroscience

·January 12, 2023·3 min read

A Key Step Toward New Treatment for Hereditary Blindness

Using animal models, researchers demonstrate a potentially effective approach to treating blindness associated with genetic conditions by using mRNA and lipid nanoparticles.

Brain Cancer Featured Neuroscience

·June 1, 2022·5 min read

Engineers Develop Nanoparticles That Cross the Blood-Brain Barrier

Researchers have developed drug-carrying nanoparticles that cross the blood-brain barrier, allowing for more effective delivery to the brain than conventional medications. The nanoparticles can get into tumors and kill glioblastoma brain cancer cells.