A new study in mice reveals a possible link between the use of SSRI antidepressants during pregnancy and an increased risk of autism-like symptoms in offspring. Offspring exposed to fluoxetine (Prozac) in utero were more likely to exhibit impaired neurotransmission caused by an overactive serotonin receptor in the prefrontal cortex, an area of the brain implicated in modulating social behaviors. However, treating the mice with a compound that blocks the receptor alleviated the behavioral problems and improved working memory.
Neuroimaging reveals those who have spent more years studying have increased cortical thickness in the medial prefrontal cortex, anterior cingulate and orbitofrontal areas of the brain. Researchers also identified enhanced gene expression profiles in these brain regions that promote information processing and provide protection against some age-related neurodegenerative diseases.
Researchers identified specific neurons in the medial prefrontal cortex, called self monitoring error neurons, that fire immediately after people make a mistake.
Researchers report older people may make riskier decisions than younger people.
Researchers report the medial prefrontal cortex calibrates current visual information with previously obtained information to help us perceive the world with more stability, helping to retain visual consistency as we blink.
A new study provides insight into the neurobiological underpinnings of envy. Researchers have identified a part of the brain that specifically registers when another receives a reward. This affects the subjective value placed on personal resources and rewards.
Researchers report a new video game aimed at middle school children can help boost empathy and prosocial behavior. The study reports children exposed to the game showed greater connectivity between brain networks linked to emotional regulation and perspective taking.
Researchers report repeated social defeat stress activates microglia in the medial prefrontal cortex, triggering inflammation related cytokines. This leads to impaired neural responses in the mPFC, resulting in depressive behavior.
Researchers report rats exposed to phthalates, both while in the womb and through lactation, had fewer neurons and synapses than peers who were not exposed to the plasticizing chemicals. Additionally, the phthalate exposed rats showed deficits in cognitive flexibility.