A person's sex is one of the main drivers of altered gene expression in motor neurons, regardless of whether they were derived from patients diagnosed with ALS. Male ALS stem cells generated significantly more motor neurons than the control group, however, this was not seen in female samples.
Study links motor neurons' large cell size and supporting structures with genes that underly vulnerability to degeneration associated with ALS.
Findings could have implications for new avenues of research for a range of neurodegenerative diseases including ALS and Alzheimer's.
Using MEG neuroimaging, researchers have identified a new marker that can be used to predict the clinical outcomes for those suffering from ALS.
Motor system neurons not only control movement, they also incite action.
Mutations in the IL18RAP gene reduce inflammation and appears to protect the brain against ALS.
PolyP, an inorganic polyphosphate released by astrocytes in people with ALS and frontotemporal dementia contributes to the signature motor neuron death associated with the disease pathologies.
Study reveals how miniature release events help to keep neurons intact and preserve motor neuron function in aging insects.
Cedars-Sinai has been awarded $11.99 million by California's stem cell agency to launch a clinical trial testing a potential gene and stem cell therapy for amyotrophic lateral sclerosis (ALS).
Using single nucleus RNA sequencing, researchers have mapped 21 subtypes of motor neurons in the spinal cords of mice.
Some neurons have the ability to detect and compensate for neighboring neurons, while others do not. The findings shed new light on synaptic plasticity.
A new study challenges the popular theory of intrinsic, dynamic patterns control motor behaviors. Researchers found neuron population dynamics in the motor cortex are different during reaching and grasping behaviors.