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LSD

·July 19, 2025·6 min read

More Than Serotonin: How Psychedelics Engage the Whole Brain

Classical psychedelics like LSD, psilocybin, and mescaline are known for activating the 5-HT2A serotonin receptor, but a new study reveals their effects go far beyond. Researchers profiled 41 psychedelics against over 300 human receptors and found potent activity at serotonin, dopamine, and adrenergic sites.

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·April 14, 2025·5 min read

LSD-Inspired Drug Reverses Psychosis Brain Damage Without Hallucinations

A new LSD-derived compound called JRT shows promise for treating schizophrenia and other brain disorders without inducing hallucinations. Developed by researchers who altered just two atoms in LSD’s structure, JRT maintains the psychedelic’s neuroplastic effects while avoiding its psychosis-linked risks.

Featured Neuroscience Psychology

·June 20, 2024·3 min read

Prior LSD Use Linked to Lower Psychological Resilience

Lifetime LSD use is linked to higher severe psychological distress after job loss, a new study reveals. Analyzing data from 15,854 adults, researchers found those with prior LSD use were 1.6-1.7 times more likely to report severe distress. The study suggests LSD does not confer resilience to stress from job loss. These findings challenge previous claims about the psychological benefits of psychedelic use.

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·January 9, 2023·12 min read

The Rebirth of Psychedelic Medicine

Often considered dangerous, mind-altering drugs, researchers are turning to the study of psychedelic therapies as a potential to treat an array of psychiatric conditions including depression and PTSD.

Featured Neuroscience Psychology

·February 17, 2022·5 min read

Study of LSD Microdosing Doesn’t Show a Therapeutic Effect

Researchers say they have found no evidence LSD microdosing improves mood or cognitive function.

Featured Neuroscience Open Neuroscience Articles Psychology

·November 23, 2021·4 min read

Psychedelic Microdosing Improves Mental Health

Microdosing psychedelics like LSD and psilocybin alleviates symptoms of depression and anxiety while improving feelings of wellbeing.

Featured Neuroscience Psychology

·November 19, 2021·5 min read

Psychedelics Show Promise in Treating Mental Illness

A growing body of evidence suggests psychedelics including psilocybin and LSD show promise in providing lasting relief from symptoms for those suffering some mental health disorders. Researchers found DOI, a similar drug to LSD, reduced negative behavioral responses following fear triggers in mouse models of anxiety.

This shows a psychedelic filter over a woman's face

Featured Neuroscience

·September 14, 2021·3 min read

LSD-Triggered Altered Behaviors Linked to Abnormal Brain Communication

Altered behaviors associated with LSD may be caused by a reduction in the normal communication between the hippocampus and visual cortex.

Featured Neuroscience Psychology

·February 21, 2021·4 min read

From Trippy Drugs to Therapeutic Aids – How Psychedelics Got Their Groove Back

From microdosing to improve cognition, to treating a range of mental health disorders, researchers evaluate the rise in the use of psychedelics and their potential as medicines.

Autism Featured Neuroscience Psychology

·January 26, 2021·5 min read

LSD May Offer Viable Treatment for Certain Mental Disorders

LSD increases social behaviors by activating 5-HTPA serotonin receptors and AMPA receptors in the prefrontal cortex, and the mTORC1 protein. Activating all three factors promoted social interactions. The findings suggest supervised LSD microdosing may help alleviate some of the social problems associated with ASD and other mental health disorders that impact social behaviors.

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·September 17, 2020·6 min read

How Psychedelics Bind to Key Serotonin Receptor

Researchers have uncovered the structure of psychedelic compounds when they actively bind to the 5-HT2A serotonin receptor on the surface of brain cells. The discovery could lead to the exploration of more precise compounds that offer the therapeutic effects of psychedelics for mental health disorders, but without the hallucinations.

Featured Neuroscience Open Neuroscience Articles Psychology

·June 5, 2020·4 min read

Psychedelic drug psilocybin tamps down brain’s ego center

Psilocybin reduces activity in the claustrum, an area of the brain believed to contribute to consciousness and sense of self. Researchers say the reduced activity may tie in with the reduced sense of self and ego often associated with psychedelic drug use. The study also reports psilocybin alters the way the claustrum communicates with brain areas involved in attention, decision making, auditory processing, and memory.