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limbic-predominant age-related TDP-43 encephalopathy

·June 13, 2022·4 min read

High Prevalence of Recently Defined Non-Alzheimer’s Dementia

The prevalence of brain changes associated with LATE, a form of dementia first identified in 2019, may be as high as 40% in older adults and 50% in those with Alzheimer's disease.

Featured Neurology Neuroscience

·December 19, 2019·4 min read

Is there a link between lifetime lead exposure and dementia?

A new hypothesis suggests declining rates of dementia could be a result of generational differences in lifetime exposure to lead.

This shows someone holding an old person's hands

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·April 30, 2019·5 min read

When is Alzheimer’s not Alzheimer’s? Researchers characterize a different form of dementia

LATE, a form of dementia that appears in the oldest-old is often mistaken for Alzheimer's disease, but the brain pathology is very different. The protein TDP-43 appears to play a significant role in the development of LATE. The neurodegenerative disease may progress more gradually than Alzheimer's, but when combined with Alzheimer's disease (a common combination), appears to cause a more rapid decline than either would alone.