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lactate

This shows a person exercising and a brain.

Featured Neuroscience Open Neuroscience Articles

·September 23, 2025·5 min read

Lactate Infusions Mimic Exercise’s Brain-Boosting Benefits

A new study shows that the brain benefits of exercise may be partly replicated with an IV infusion of lactate, the by-product of intense physical activity. Researchers found that such infusions increased pro-BDNF levels in the blood—molecules linked to brain growth and resilience—without requiring exercise.

Featured Neuroscience

·October 4, 2024·5 min read

New Molecule Mimics Exercise and Fasting Effects

Researchers have developed a molecule called LaKe that mimics the metabolic effects of strenuous exercise and fasting. This molecule increases lactate and ketone levels in the body, providing similar benefits to running 10 kilometers on an empty stomach, without physical exertion or dietary changes.

Autism Featured Neurology Neuroscience

·March 26, 2024·6 min read

Altered Brain pH Linked to Cognitive Disorders

A global study involving 131 researchers from 105 labs across seven countries has found altered brain pH and lactate levels across various animal models of neuropsychiatric and neurodegenerative disorders. This large-scale research reveals a common endophenotype involving energy metabolism dysfunction as a hallmark in disorders such as schizophrenia, autism, and Alzheimer’s.

Featured Neuroscience

·July 24, 2023·4 min read

Neuronal Boost: Lactate’s Key Role in Brain Development Uncovered

Researchers discovered the critical role lactate plays in the development of neural stem cells into specialized neurons. They found that lactate sends signals to these cells, aiding in the modification and strengthening of neuronal functions.

Brain Cancer Featured Neuroscience Open Neuroscience Articles

·July 22, 2022·4 min read

New Biomimetic Formulation for Treating Glioblastoma

Researchers found a positive correlation between glioblastoma cell proliferation and lactate metabolic indicators. Based on this observation, the researchers developed a biomimetic formulation using targeted delivery agents for lactate metabolism-based synergistic therapy against glioblastoma brain cancer.

Featured Neuroscience Open Neuroscience Articles Psychology

·October 12, 2021·3 min read

Protein Lactylation Is Induced in the Brain by Neural Activation and Social Stress

In mice, protein lactylation occurs in neurons and is correlated with lactate levels. Protein lactylation is enhanced by neural excitation and social stress. Researchers found social stress specifically enhances lysine lactylation of histone H1 proteins.

Featured Neurology Neuroscience

·September 16, 2020·5 min read

New Path to Neuron Regeneration After Spinal Cord Injury Discovered

Axon regeneration and dramatic improvements in functional recovery occurred when lactate was applied to damaged neural tissue. Treatment with lactate also significantly improved locomotion and restored some walking capability in mouse models of SCI.

Featured Neuroscience Psychology

·August 7, 2017·5 min read

Brain Acidity Imbalance in Psychiatric Disorders

Researchers discover imbalanced pH and lactate levels in the brains of mouse models of schizophrenia, ASD and bipolar disorder. They believe the imbalances could reflect an underlying pathophysiology to some psychiatric disorders.