Neurexin regulates the survival of cerebellar granule cells independently of synapses. The findings shed new light on the mechanisms behind neurodevelopmental disorders like schizophrenia and ASD.
Participating in exercise improved synaptic pruning in mouse models of autism. The study also found microglia dependant synaptic pruning is impaired by maternal inflammation, which has been previously connected to the development of ASD.
Chemically activating neurons and placing mice in stimulating environments reverses alterations and restores some neural connectivity in frontotemporal dementia. If translated into humans, the findings could help develop new treatments for fighting the effects of dementia in the elderly.
A new study reveals how a prion-like protein that is encoded by the TIA1 gene helps to regulate fear memories. TIA1, researchers report, may be a promising new target for the treatment of PTSD.
Researchers report newborn granule cells in the dentate gyrus become less excitable after three weeks. The loss of excitability is crucial for the functioning of mature neurons.
A new study could shed light on how the cerebellum encodes information.
Inhibitory neurons form neural networks that become broader as they mature, a new study reports.
Researchers report altering synaptic plasticity leads to a computational switch in a hippocampal synapse which turns the presynaptic neuron turns into “detonator” mode, causing it to fire more readily.